Publications by authors named "Tom Eisenreich"
Article Synopsis
- Chronic infection with Plasmodium falciparum is linked to Burkitt's lymphoma, a B cell cancer, though the specific mechanisms are still unclear.
- Researchers used Plasmodium chabaudi in mice to study how chronic malaria infection affects B cell lymphoma development.
- Infection leads to prolonged germinal center (GC) activation and DNA damage in B cells, promoting mature B cell lymphomas that are dependent on the AID enzyme and associated with chromosome translocations.
Innate sensing mechanisms trigger a variety of humoral and cellular events that are essential to adaptive immune responses. Here we describe an innate sensing pathway triggered by Plasmodium infection that regulates dendritic cell homeostasis and adaptive immunity through Flt3 ligand (Flt3l) release. Plasmodium-induced Flt3l release in mice requires Toll-like receptor (TLR) activation and type I interferon (IFN) production.
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