Synergistic interaction between amyloid and tau predicts the progression to dementia.

Introduction: Recent literature proposes that amyloid β (Aβ) and phosphorylated tau (p-tau) synergism accelerates biomarker abnormalities in controls. Yet, it remains to be answered whether this synergism is the driving force behind Alzheimer disease (AD) dementia.

Methods: We stratified 314 mild cognitive impairment individuals using [F]florbetapir positron emission tomography Aβ imaging and cerebrospinal fluid p-tau.