Publications by authors named "Tom A Reynolds"
Purpose: We sought to evaluate the incidence, natural history, and management of cystic spinal lesions following myelomeningocele/myeloschisis closure.
Methods: We performed a single-center retrospective review of all patients who underwent myelomeningocele/myeloschisis closure from 2013 to 2018 with follow-up to 5 years old.
Results: We analyzed 100 fetal repairs and 81 postnatal closures from 305 total surgeries.
Objective: Hindbrain herniation (HH) is a clinical prerequisite for prenatal repair of myelomeningocele/myeloschisis; however, a subset of patients lack HH on initial fetal imaging and may ultimately progress to exhibit herniation on subsequent prenatal or postnatal imaging. The authors sought to explore the cohort of patients without HH at the time of initial fetal consultation for myelomeningocele/myeloschisis repair to define their clinical characteristics and outcome.
Methods: From July 2016 to July 2022, patients evaluated at the Children's Hospital of Philadelphia Center for Fetal Diagnosis and Treatment for myelomeningocele/myeloschisis were classified into two cohorts: those with and those without HH.
Article Synopsis
- This study investigates neurodevelopmental outcomes and seizure onset in early childhood for patients with myelomeningocele and periventricular nodular heterotopia.
- Out of 497 patients analyzed, only a portion had confirmed PVNH, but its presence was not linked to higher risk of seizures or significant differences in neurodevelopmental scores.
- The findings suggest that PVNH does not correlate with neurodevelopmental delays at one year old, prompting a need for long-term follow-up to better understand its effects.