The influence of the 4th industrial revolution on family cohesion-A systematic review protocol.

Humanity may be facing untold threats and possible benefits as a result of the burgeoning 4th Industrial Revolution. New technologies introduced by the 4th Industrial Revolution have been purported to be gradually diminishing humans' capacities like compassion and cooperation. Challenges such as security, trust, liability and personal data privacy issues are also being triggered which calls for stricter regulations.

An Assessment of Systemic Factors and COVID-19 Mortality in Africa.

The objective of this study was to examine the association between several country-level systemic indices and the deaths from COVID-19 across African countries. Regression analyses were conducted to test the association between selected indices and deaths from COVID-19 across African countries. All tests were run at the = 0.

Efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV infected children and adolescents: a systematic review and meta-analysis.

Background: Abacavir is one of the recommended nucleoside reverse transcriptase inhibitors (NRTIs) for the treatment of HIV infections among children and adolescents. However, there are concerns that the antiviral efficacy of abacavir might be low when compared to other NRTIs especially among children. There are also concerns that abacavir use may lead to serious adverse events such as hypersensitivity reactions and has potential predisposition to developing cardiovascular diseases

Methods: We searched four electronic databases, four conference proceedings and two clinical trial registries in August 2014, without language restrictions.

Antiretroviral Treatment and Resistance Patterns in HIV-Infected Children.

Paediatric HIV-infected patients have higher risk of developing resistance to antiretroviral drugs, and from public health perspective, drug resistance remains a limiting factor for effective management of HIV infection in children. We reviewed the current evidences available on the antiretroviral treatment and resistance patterns in HIV-infected children. Prevalence of HIV drug resistance varied among the three main classes of antiretroviral drugs, namely nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors in both treatment naïve and treatment-experienced children in different countries.