Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration.

Cardiovascular diseases are a significant cause of illness and death worldwide, often resulting in myofibroblast differentiation, pathological remodeling, and fibrosis, characterized by excessive extracellular matrix protein deposition. Treatment options for cardiac fibrosis that can effectively target myofibroblast activation and ECM deposition are limited, necessitating an unmet need for new therapeutic approaches. In recent years, microcurrent therapy has demonstrated promising therapeutic effects, showcasing its translational potential in cardiac care.

ERPs and alpha oscillations track the encoding and maintenance of object-based representations in visual working memory.

When memorizing an integrated object such as a Kanizsa figure, the completion of parts into a coherent whole is attained by grouping processes which render a whole-object representation in visual working memory (VWM). The present study measured event-related potentials (ERPs) and oscillatory amplitudes to track these processes of encoding and representing multiple features of an object in VWM. To this end, a change detection task was performed, which required observers to memorize both the orientations and colors of six "pacman" items while inducing configurations of the pacmen that systematically varied in terms of their grouping strength.

Little engagement of attention by salient distractors defined in a different dimension or modality to the visual search target.

Singleton distractors may inadvertently capture attention, interfering with the task at hand. The underlying neural mechanisms of how we prevent or handle distractor interference remain elusive. Here, we varied the type of salient distractor introduced in a visual search task: the distractor could be defined in the same (shape) dimension as the target, a different (color) dimension, or a different (tactile) modality (intra-dimensional, cross-dimensional, and, respectively, cross-modal distractor, all matched for physical salience); and besides behavioral interference, we measured lateralized electrophysiological indicators of attentional selectivity (the N2pc, Ppc, P , CCN/CCP, CDA, and cCDA).

Hierarchy of Intra- and Cross-modal Redundancy Gains in Visuo-tactile Search: Evidence from the Posterior Contralateral Negativity.

Redundant combination of target features from separable dimensions can expedite visual search. The dimension-weighting account explains these "redundancy gains" by assuming that the attention-guiding priority map integrates the feature-contrast signals generated by targets within the respective dimensions. The present study investigated whether this hierarchical architecture is sufficient to explain the gains accruing from redundant targets defined by features in different modalities, or whether an additional level of modality-specific priority coding is necessary, as postulated by the modality-weighting account (MWA).

EEG evidence for enhanced attentional performance during moderate-intensity exercise.

Research on attentional control within real-world contexts has become substantially more feasible and thus frequent over the past decade. However, relatively little is known regarding how these processes may be influenced by common naturalistic behaviors such as engaging in physical activity, which is thought to modulate the availability of neurometabolic resources. Here, we used an event-related potential (ERP) approach to determine whether various intensities of aerobic exercise might affect the concurrent performance of attentional control mechanisms.

Automatic Guidance (and Misguidance) of Visuospatial Attention by Acquired Scene Memory: Evidence From an N1pc Polarity Reversal.

Visual search is facilitated when the target is repeatedly encountered at a fixed position within an invariant (vs. randomly variable) distractor layout-that is, when the layout is learned and guides attention to the target, a phenomenon known as . Subsequently changing the target location within a learned layout abolishes contextual cuing, which is difficult to relearn.

Neural differences between chromatic- and luminance-driven attentional salience in visual search.

Previous electroencephalographic research on attentional salience did not fully capture the complexities of low-level vision, which relies on both cone-opponent chromatic and cone-additive luminance mechanisms. We systematically varied color and luminance contrast using a visual search task for a higher contrast target to assess the degree to which the salience-computing attentional mechanisms are constrained by low-level visual inputs. In our first experiment, stimuli were defined by contrast that isolated chromatic or luminance mechanisms.

Electroencephalographic evidence for improved visual working memory performance during standing and exercise.

While a substantial body of research has investigated the effects of aerobic exercise on cognitive performance, few have monitored exercise-concurrent cognitive processes via electroencephalography and fewer still using an event-related potential (ERP) approach. As such, little is known regarding how the temporal dynamics of cognitive processing are influenced during aerobic activity. Here, we aimed to elucidate the influence of aerobic exercise on the temporal dynamics of concurrent visual working memory (VWM) performance.

Sex differences in the neural underpinnings of social and monetary incentive processing during adolescence.

The brain's reward system undergoes major changes during adolescence, and an increased reactivity to social and nonsocial incentives has been described as a typical feature during this transitional period. Little is known whether there are sex differences in the brain's responsiveness to social or monetary incentives during adolescence. The aim of this event-related potential (ERP) study was to compare the neurophysiological underpinnings of monetary and social incentive processing in adolescent boys versus girls.

Item-based selection is in good shape in visual compound search: A view from electrophysiology.

We argue that although the framework put forward by Hulleman & Olivers (H&O) can successfully explain much of visual search behaviour, it appears limited to tasks without precise target identification demands. In particular, we contend that the unit of selection may be larger than a single item in standard detection tasks, whereas the unit may mandatorily be item-based in compound tasks.

Event-related Electroencephalographic Lateralizations Mark Individual Differences in Spatial and Nonspatial Visual Selection.

Selective attention controls the distribution of our visual system's limited processing resources to stimuli in the visual field. Two independent parameters of visual selection can be quantified by modeling an individual's performance in a partial-report task based on the computational theory of visual attention (TVA): (i) top-down control α, the relative attentional weighting of relevant over irrelevant stimuli, and (ii) spatial bias w, the relative attentional weighting of stimuli in the left versus right hemifield. In this study, we found that visual event-related electroencephalographic lateralizations marked interindividual differences in these two functions.

Object maintenance beyond their visible parts in working memory.

Completion of a partially occluded object requires that a representation of the whole is constructed based on the information provided by the physically specified parts of the stimulus. Such processes of amodal completion rely on the generation and maintenance of a mental image that renders the completed object in visual working memory (VWM). The present study examined this relationship between VWM storage and processes of object completion.

Attentional capture in visual search: Capture and post-capture dynamics revealed by EEG.

Sometimes, salient-but-irrelevant objects (distractors) presented concurrently with a search target cannot be ignored and attention is involuntarily allocated towards the distractor first. Several studies have provided electrophysiological evidence for involuntary misallocations of attention towards a distractor, but much less is known about the mechanisms that are needed to overcome a misallocation and re-allocate attention towards the concurrently presented target. In our study, electrophysiological markers of attentional mechanisms indicate that (i) the distractor captures attention before the target is attended, (ii) a misallocation of attention is terminated actively (instead of attention fading passively), and (iii) the misallocation of attention towards a distractor delays the attention allocation towards the target (rather than just delaying some post-attentive process involved in response selection).

Two Independent Frontal Midline Theta Oscillations during Conflict Detection and Adaptation in a Simon-Type Manual Reaching Task.

One of the most firmly established factors determining the speed of human behavioral responses toward action-critical stimuli is the spatial correspondence between the stimulus and response locations. If both locations match, the time taken for response production is markedly reduced relative to when they mismatch, a phenomenon called the Simon effect. While there is a consensus that this stimulus-response (S-R) conflict is associated with brief (4-7 Hz) frontal midline theta (fmθ) complexes generated in medial frontal cortex, it remains controversial (1) whether there are multiple, simultaneously active theta generator areas in the medial frontal cortex that commonly give rise to conflict-related fmθ complexes; and if so, (2) whether they are all related to the resolution of conflicting task information.

Neurophysiological Mechanisms of Auditory Information Processing in Adolescence: A Study on Sex Differences.

To date, little is known about sex differences in the neurophysiological correlates underlying auditory information processing. In the present study, auditory evoked potentials were evoked in typically developing male (n = 15) and female (n = 14) adolescents (13-18 years) during an auditory oddball task. Girls compared to boys displayed lower N100 and P300 amplitudes to targets.

Attending to multiple objects relies on both feature- and dimension-based control mechanisms: Evidence from human electrophysiology.

Numerous everyday search tasks require humans to attentionally select and temporally store more than one object present in the visual environment. Recently, several enumeration studies sought to isolate the mechanisms underlying multiple object processing by means of electrophysiological measures, which led to a more fine-grained picture as to which processing stages are modulated by object numerosity. One critical limitation that most of these studies share is that they used stimulus designs in which multiple targets were exclusively defined by the same feature value.

EEG correlates of visual short-term memory as neuro-cognitive endophenotypes of ADHD.

Attention deficit hyperactivity disorder (ADHD) frequently persists into adulthood. A reduction in visual short-term memory (vSTM) storage capacity was recently suggested as a potential neuro-cognitive endophenotype, i.e.

Age-related decline in global form suppression.

Visual selection of illusory 'Kanizsa' figures, an assembly of local elements that induce the percept of a whole object, is facilitated relative to configurations composed of the same local elements that do not induce a global form--an instance of 'global precedence' in visual processing. Selective attention, i.e.

Progesterone Accelerates the Completion of Sperm Capacitation and Activates CatSper Channel in Spermatozoa from the Rhesus Macaque.

During transit through the female reproductive tract, mammalian spermatozoa are exposed to increasing concentrations of progesterone (P4) released by the cumulus oophorus. P4 triggers massive calcium influx into human sperm through activation of the sperm-specific calcium channel CatSper. These properties of human spermatozoa are thought to be unique since CatSper is not progesterone sensitive in rodent sperm.

The Speed of Visual Attention and Motor-Response Decisions in Adult Attention-Deficit/Hyperactivity Disorder.

Background: Adults with attention-deficit/hyperactivity disorder (ADHD) exhibit slowed reaction times (RTs) in various attention tasks. The exact origins of this slowing, however, have not been established. Potential candidates are early sensory processes mediating the deployment of focal attention, stimulus response translation processes deciding upon the appropriate motor response, and motor processes generating the response.

The Right Angular Gyrus Combines Perceptual and Response-related Expectancies in Visual Search: TMS-EEG Evidence.

Background: Visual search performance is sensitive to changes in the environment. Attention is sensitive to trial history, in terms of both perception and response. Although the bases of these sensorimotor interactions remain unclear, both behaviorally and neurally, converging evidence from a variety of methods indicates that the right angular gyrus (rANG) may be important.

Searching for targets in visual working memory: investigating a dimensional feature bundle (DFB) model.

The human visual working memory (WM) system enables us to store a limited amount of task-relevant visual information temporally in mind. One actively debated issue in cognitive neuroscience centers around the question of how this WM information is maintained. The currently dominant views advocated by prominent WM models hold that the units of memory are configured either as independent feature representations, integrated bound objects, or a combination of both.

Predictive distractor context facilitates attentional selection of high, but not intermediate and low, salience targets.

It is well established that we can focally attend to a specific region in visual space without shifting our eyes, so as to extract action-relevant sensory information from covertly attended locations. The underlying mechanisms that determine how fast we engage our attentional spotlight in visual-search scenarios, however, remain controversial. One dominant view advocated by perceptual decision-making models holds that the times taken for focal-attentional selection are mediated by an internal template that biases perceptual coding and selection decisions exclusively through target-defining feature coding.