S-nitrosothiols, nitric oxide and proinflammatory cytokines in children with inflammatory bowel disease.

Background: The aim of the study was to investigate the levels of S-nitrosothiols (RSNO) in blood serum of children with inflammatory bowel disease (IBD), nonspecific ulcerative colitis (NUC) and Crohn's disease (CD), and correlate the obtained data with the number of total nitric oxide metabolites (NOx) and proinflammatory cytokines (PC).

Methods: RSNO and NOx were determined by the Griess method and PC by ELISA. We examined 174 children of both genders aged from 6 to 17 years (mean age - 14 years) including 112 children suffering from IBD and 62 children from the control group.

The (137)Cs accumulation by forest-derived products in the Gomel region.

This paper reports basic features of the (137)Cs uptake by forest-derived products in the Gomel region. Even with the soil contamination density of 37 kBq m(-2) the radionuclide contents in 20-30% of mushrooms and berries were found to be higher than the admissible levels. The (137)Cs contamination density of soil, site type and meteorological parameters were observed as the major factors which govern the radiocaesium uptake by mushrooms and berries.

The impact of informal care-giving networks on adult children's care-giver burden.

Previous research on the care-giver burden experienced by adult children has typically focused on the adult child and parent dyad. This study uses information on multiple informal care-givers and examines how characteristics of the informal care-giving network affect the adult child's care-giver burden. In 2007, 602 Dutch care-givers who were assisting their older parents reported on parental and personal characteristics, care activities, experienced burden and characteristics of other informal care-givers.

[Effect of the biopreparation "Polyene" on parameters of blood fatty acid composition in volleyball athletes].

Influence of the preparation "Polyen" has been studied on indexes of lipid acids contents in blood plasma, erythrocyte membrane and serum albumin of high-qualified volleyball-players. It was shown that "Polyen" has favourable effect on different metabolic pathways of lipid acids, that allow to recommend this preparation as additional component in food ration for training sportsmen.

[The effect of biological food supplements containing polyunsaturated fatty acids on the erythrocyte enzyme activity and on the hemoglobin oxygen affinity in volleyball players exposed to intensive physical loading].

It has been determined that in erythrocytes of professional volley-ball players given biopreparation "Polien" containing polyunsaturated fatty acids glycolysis and pentose phosphate pathway reactions are intensified and glutathione reductase activity decreased. At the same time the affinity of haemoglobin to oxygen stabilized in the sportsmen before and after intensive muscle load.

[State of local immunity under exposure to anthropogenic factors of biological, chemical and physical nature in industry].

The authors studied immunologic features of saliva in 1714 workers exposed to vibration and other occupational hazards in microbiologic, chemical enterprises. The examinees demonstrated lower activity of lysozyme and concentrations of IgA, higher levels of IgG. Immunologic features of saliva was proved to have extreme diagnostic importance, therefore could be used to detect early signs of exposure to occupational hazards and to diagnose pathologic conditions caused by those hazards.

[Lipid composition of blood plasma and erythrocyte membrane of volleyball players under intensive physical load].

As the result of prolonged training activity highly skilled volleyball players have marked deficiency of fatty acids of w3 family both in the blood plasma as erythrocyte membranes. These acids may be used in the lipid peroxidation processes, that is proved by the facts of POL products content and their drawing into oxidation reaction, which is certified by high level of ATP in erythrocytes. Reduction of quantity of polyunsaturated fatty acids of w3 family may be regarded as results of their insufficient arrival with food.

[Changes in the fatty acid composition of serum albumin in patients with lung and breast neoplasms].

Serum albumin fatty acid composition of patients with lung and mammary gland oncopathology was investigated by chromatography method. Differences in the contents of families 6 and 3 fatty acids were showed that depend on disease stage and tumour localization. omega 6/ omega 3 ratio increase in the early stages of tumour process was established for both pathologies.

[The indices of intraerythrocyte metabolism and hemoglobin oxygen affinity in volleyball players under intensive physical loads].

The authors' investigations led them to the conclusion that skilled volleyball players' erythrocytes undergo adaptive metabolic rearrangement. There was also low hemoglobin affinity to oxygen. A single training load provoked the effect of metabolic enhancement as a result of increased red cell concentration of glucose, glycosylated hemoglobin and high activity of hexokinase.

[Features of transport function and structure of serum albumin in cancer].

Levels of lipid ligands in serum albumin from cancer patients were assayed versus tumor localization. Abnormal non-specific increase in albumin-bound lipids as well as in peroxidation products was found. Gas-liquid chromatography of different polynonsaturated fatty acids pointed to the enhancement of their metabolism via the omega 3 pathway.

[Features of the structure and fatty acid composition of serum albumin in experimental myocarditis].

Properties of animal serum albumin transport and its structure were studied in experimental myocarditis. The data obtained suggest that impairments in myocardium were of chronic and recurring type. The albumin exhibited a high structure-functional variability.

[The characteristics of lipid ligand binding by serum albumin in athletes].

The ability of serum albumin to bind lipids, fatty acids and products of their peroxidation was studied in well trained sportsmen during a competitive period. Detected quantitative and qualitative alterations point to a protein involvement in metabolic changes in an adaptation to work loads.

[Functional properties of blood proteins in highly trained athletes].

The functional properties of serum albumin and hemoglobin were investigated in highly trained athletes. During adaptation to regular strenuous exercise, the metabolic pathway of omega 3 fatty acids intensified and the content of lipid peroxidation products in serum albumin increased. Also, hemoglobin affinity for molecular oxygen decreased and ATP concentration in red blood cells increased.

[A structural-functional assessment of serum albumin in cancerous diseases].

HSA structure was studied in healthy subjects and cancer patients using infrared spectroscopy. No significant differences were observed although the intensity of valent C-H fluctuation lines in alkyl groups of HSA was slightly increased in cancer patients. Gas-liquid chromatography established changes in the profile of polyunsaturated fatty acids binding to HSA in cancer patients.

[Incidence of immune deficiency in children population from industrial city].

The authors relate the data on the incidence of different forms of immune deficiency (ID). The studies were carried out within the framework of the All-Union program of mass immunoepidemiological screenings, among the childhood population of industrial city numbering 59,178 persons. The primary group at ID risk amounting to 2.

[Functional disorders of the cardiovascular system in patients with acute suppurative puerperal mastitis].

On 82 patients with suppurative puerperal mastitis, in 25 (30.5%) the disorders in function of the cardiovascular system were revealed. The disorders directly depended on the severity of the disease.

[Study of lipid ligands in serum albumin in sportsmen using thin layer chromatography].

Lipid composition and the ability of serum albumin to bind lipid components and products of their peroxidation were investigated in cyclists of different rating during moderate workloads. Ratios of subfractions of phospholipids and other lipid metabolites in blood serum albumin were determined by the method of thin-layer chromatography. Diene conjugates and diene ketones were found to be actively formed in plasma of highly trained cyclists in whom a high lipid capacity of albumin was associated with its low affinity for lipid hydroperoxides.