Impact of COVID-19 on older adults with cancer and their caregivers' cancer treatment experiences study: The ICE-OLD study.

The COVID-19 pandemic and health services impacts related to physical distancing posed many challenges for older adults with cancer. The goal of this study was to examine the impact of the pandemic on cancer treatment plans and cancer treatment experiences of older adults (ie, aged 65 years and older) and their caregiver' experiences of caring for older adults during the pandemic to highlight gaps in care experienced. In this multi-centre qualitative study guided by an interpretive descriptive research approach we interviewed older adults diagnosed with cancer and caregivers caring for them.

Symptom experiences of older adults during treatment for metastatic prostate cancer: A qualitative investigation.

Introduction: Exploring symptom experiences of older men during metastatic prostate cancer treatment can help clinicians identify unmet supportive care needs that, if addressed, could improve toxicity management and enhance patient wellbeing. Previous qualitative studies of older adults with advanced prostate cancer have focused on the psychological experience rather than the overall symptom experience. Therefore, the objective of this study was to understand the lived experience of symptoms and supportive care needs in older men undergoing treatment for metastatic prostate cancer.

Ultrasonographic measurements of the omohyoid muscle during shoulder muscles contraction.

Background: The main function of the omohyoid muscle is to depress and withdraw the hyoid bone. This is an integral part of the swallowing process facilitating hyoid stabilization for tongue movement. Although the muscle is inferiorly attached to the scapula bone, its function during shoulder or scapula muscles contraction has yet not been studied.

Care provided by older adult caregivers to a spouse in active cancer treatment: a scoping review.

Purpose: Due to population aging, the number of older adults with cancer will double in the next 20 years. There is a gap in research about older adults who are the caregiver of a spouse with cancer. Therefore, this review seeks to answer the overarching research question: What is known about the association of providing care on Health-Related Quality of Life (HRQOL), psychological distress, burden, and positive aspects of caregiving for an older adult caregiver to a spouse with cancer?

Methods: This scoping review was guided by the framework of Arksey and O'Malley and refined by Levac et al.

Romantic Competence and Adolescent Courtship: The Multidimensional Nature of the Construct and Differences by Age and Gender.

Adolescent courtship is emerging as an important developmental process which impacts social balance and adjustment in the teenage years. Both the cultural context and different individual competencies seem to determine the success or failure of this process. However, there is little research focusing on the direct relationship between interpersonal skills and adolescent courtship, possibly due to the lack of suitable instruments to measure it.

Balanced (endoscopic medial and transcutaneous lateral) orbital decompression in Graves' orbitopathy.

Background: To determine the clinical outcomes and morbidity of endoscopic medial wall combined with transcutaneous lateral orbital wall decompression in Graves' orbitopathy.

Methodology: A retrospective noncomparative case series of patients who underwent surgical decompression for Graves' orbitopathy at Hospital Universitario de Fuenlabrada between 2004 and 2014 was performed. We reviewed the patients' charts and analyzed before and after the decompression, the visual acuity (Snellen chart), optic nerve compression (fundoscopy and optic coherence tomography), exophthalmometry (Hertel measurement), ocular motility, diplopia, eyelid surgery needed after decompression and its possible complications.

Intratesticular and incisional line infiltration with ropivacaine for castration in medetomidine-butorphanol-midazolam sedated dogs.

Objective: To evaluate whether intratesticular and incisional ropivacaine infiltration produces sufficient intra- and postoperative analgesia for castrating dogs under sedation.

Study Design: Randomized, blinded, controlled clinical study.

Animals: Twenty-three healthy dogs weighing 5.

Diplopia due to barotrauma.

Case Report: A 38-year-old woman who, during a scuba dive at 7 metres, suffered from eye pain, hyperaemia, and exophthalmos. She was diagnosed with ocular barotrauma with transient diplopia. She was seen in the emergency room 10 days later, with no diplopia, but mild left proptosis.

[Cilioretinal artery occlusion in hemochromatosis].

Clinical Case: We report a case of a 31 year-old woman with a sudden visual loss due to a cilioretinal artery occlusion. The physical examinination showed hepatomegaly. Serum iron and ferritin and transferrin saturation were unusually high.

[Endoscopic dacryocystorhinostomy: role of the ophthalmologist].

Objective: To evaluate the results of endoscopic dacryocystorhinostomy (DCR) with or without support of the ophthalmologist.

Material And Methods: A retrospective study of 100 cases of endoscopic DCR surgery conducted by an otolaryngologist between June 2008 and December 2009. Of the 100 cases, 50 were operated with surgical support of the ophthalmologist, who inserted Bowman probes in the upper and lower canaliculi, while in the other 50 cases it was the otolaryngologist who performed this, without support of the ophthalmologist.

Novel CD47: SIRPα dependent mechanism for the activation of STAT3 in antigen-presenting cell.

Cell surface CD47 interacts with its receptor, signal-regulatory-protein α (SIRPα) that is expressed predominantly on macrophages, to inhibit phagocytosis of normal, healthy cells. This "don't eat me" signal is mediated through tyrosine phosphorylation of SIRPα at the cytoplasmic ITIM motifs and the recruitment of the phosphatase, SHP-1. We previously revealed a novel mechanism for the activation of the STAT3 pathway and the regulation of human APC maturation and function that is based on cell:cell interaction.

Cell derived liposomes expressing CCR5 as a new targeted drug-delivery system for HIV infected cells.

Anti-retroviral-therapies against HIV/AIDS focus on inhibiting viral growth and may slow AIDS progression, but not cure the disease. Here we describe an approach to treat HIV as a cellular pathology by targeting cell derived liposomes against HIV-infected cells. Cell-derived-liposomes were prepared from the cytoplasmatic membranes of cells expressing CCR5, the human receptor for gp120, that is found on the surface of virions and HIV-infected cells.

Surgical treatment of familial dacryocystocele and lacrimal puncta agenesis.

Bilateral agenesis of the lacrimal puncta and enlargement of the nasolacrimal canal are rare anatomic variants. The authors present 2 familial cases: a 39-year-old woman with bilateral dacryocystocele and lacrimal puncta agenesis and her 46-year-old brother, who had a long history of epiphora and recurrent dacryocystitis, and also had bilateral lacrimal puncta agenesis and a left dacryocystocoele. The authors report the endoscopic, CT, and MRI findings, and describe the surgical treatments, by endoscopic dacryocystorhinostomy in the first case, and conjunctivodacryocystorhinostomy with Jones tube in the second case.

Frosted branch angiitis and late peripheral retinochoroidal scar in a patient with acquired toxoplasmosis.

Purpose: To report a case of acute frosted branch angiitis associated with acquired toxoplasmosis in which a late peripheral chorioretinal scar developed.

Results: A 32-year-old man without systemic symptoms presented with sudden visual loss in his left eye. Examination demonstrated frosted branch angiitis without necrotizing chorioretinitis.

Resolution of epiphora with nasolacrimal stents: results of long-term follow-up in a multicenter prospective study.

Purpose: To evaluate in a prospective, multicenter setting the long-term effectiveness of polyurethane stents in the percutaneous management of epiphora.

Materials And Methods: Patients (n = 426; age range, 19-88 years, mean, 48; 91 men, 335 women) with severe epiphora had stents (470 eyes/496 stents) inserted to treat unilateral or bilateral and complete or partial obstruction of the nasolacrimal system. The etiology of the obstruction was idiopathic in 280 cases (59.

Severe keratomycosis secondary to Scedosporium apiospermum.

Purpose: To report an unusual case of severe keratomycosis caused by Scedosporium apiospermum without any known previous ocular injury, that resulted in a corneal perforation, which was treated with an emergency penetrating tectonic keratoplasty and later with phacoemulsification and astigmatic keratotomy to restore good visual function.

Methods: A 45-year-old woman with a history of multiple sclerosis presented with a severe and refractory corneal abscess in her right eye without any known prior injury. Corneal scrapings were obtained and stained for microscopic evaluation.

Nasolacrimal stents in the management of epiphora: medium-term results of a multicenter prospective study.

Purpose: To evaluate in a prospective multicenter setting the clinical utility of polyurethane stents in the percutaneous management of epiphora.

Materials And Methods: Patients (N = 163; age range = 22-85 y, mean = 52 y; 29 men, 134 women) with severe epiphora had stents (n = 183) inserted under fluoroscopic guidance in 180 lacrimal systems (unilateral = 146; bilateral = 17) to treat complete (n = 172) or partial (n = 8) obstruction of the nasolacrimal duct or sac. The junction between sac and duct was the most frequent location (n = 102), followed by the sac alone (n = 48), and the duct alone (n = 30).

Long-term results of TPMT activity monitoring in azathioprine-treated renal allograft recipients.

Thiopurine methyltransferase (TPMT) is implicated in the metabolism of azathioprine. The consequences of differential TPMT activity induction by azathioprine on the long-term results after renal transplantation were investigated. The erythrocyte TPMT activity in 82 patients on days 0, 7, and 30 was prospectively evaluated.

Peripheral melt of flap after laser in situ keratomileusis.

Background: Laser in situ keratomileusis (LASIK) is an effective procedure to correct myopia. It may have complications related to the flap, such as epithelial ingrowth and stromal melt.

Methods: We report on a patient who developed extensive epithelial ingrowth and partial keratolysis of the flap following LASIK.

Deposits of topical norfloxacin in the treatment of bacterial keratitis.

Purpose: Fluoroquinolone solutions are widely used in therapy of bacterial keratitis. These drugs are safe, and their ocular side effects are mild and not serious in nature. The most frequent untoward effect associated with ciprofloxacin therapy has been a white crystalline deposit.

Management and treatment of central steep islands after excimer laser photorefractive keratectomy.

Background: Permanent central steep islands are an undesirable phenomenon that cause distorted images and a significant reduction in visual acuity. We describe treatment of central steep islands with repeat excimer laser photoablation in the central cornea.

Methods: Three patients with preoperative refractions of -7.