The Development and Testing of a Patient Decision Aid for Individuals with Homologous Recombinant Proficient Ovarian Cancer Who Are Considering Niraparib Maintenance Therapy.

New treatments for ovarian cancer are available that require trade-offs between progression-free survival and quality of life. The aim of this study was to develop a decision aid for patients with homologous recombinant proficient (HRP) tumors, as the benefit-harm ratio of niraparib needs consideration. This decision aid was created with a systematic and iterative development process based on the Ottawa Decision Support Framework.

Quantum monodromy in NCNCS - direct experimental confirmation.

Since the first confirmation of quantum monodromy in NCNCS (B. P. Winnewisser , Report No.

Laser-based spectroscopy of FeD: Excitations to the g Φ electronic state.

Bands of the g Φ-X Δ, g Φ-A Π, g Φ-a Δ, and g Φ-b Π electronic transitions of iron monodeuteride (FeD) have been measured in laser excitation and in dispersed fluorescence. The molecules were produced both in a cold supersonic molecular jet source and in a chemical reaction between iron pentacarbonyl [Fe(CO)] and a microwave discharge of argon and hydrogen gases. Dispersed fluorescence from the latter source was detected at high resolution with a Fourier transform spectrometer, yielding a large number of the transitions observed.

High-Resolution Far-Infrared Spectroscopy of N-Substituted Two-Ring Polycyclic Aromatic Hydrocarbons: An Extended Study.

Polycyclic aromatic hydrocarbons (PAHs) and their N-substituted derivatives are among the largest species for which gas-phase high-resolution spectroscopy can be performed nowadays. In this paper we report the observation and analysis of spectra from several N-substituted two-ring PAHs, all taken in the "fingerprint" far-infrared region (<850 cm(-1)). Together with accurate measurements of their pure rotational transitions in the millimeter and submillimeter ranges, these synchrotron-based Fourier transform infrared (FTIR) measurements provide an accurate description of the rotational energy levels in the ground and low-energy excited vibrational states of these species.

Pursuit of quantum monodromy in the far-infrared and mid-infrared spectra of NCNCS using synchrotron radiation.

Quantum monodromy has a dramatic and defining impact on all those physical properties of chain-molecules that depend on a large-amplitude bending coordinate, including in particular the distribution of the ro-vibrational energy levels. As revealed by its pure rotational (a-type) spectrum [B. P.

Far-infrared spectrum of S(CN)2 measured with synchrotron radiation: global analysis of the available high-resolution spectroscopic data.

The high resolution Fourier transform spectrum of the chemically challenging sulfur dicyanide, S(CN)2, molecule was recorded at the far-infrared beamline of the synchrotron at the Canadian Light Source. The spectrum covered 50-350 cm(-1), and transitions in three fundamentals, ν4, ν7, and ν8, as well as in the hot-band sequence (n + 1)ν4 - nν4, n = 1-4, have been assigned and measured. Global analysis of over 21,300 pure rotation and rotation vibration transitions allowed determination of precise energies for 12 of the lowest vibrationally excited states of S(CN)2, including the five lowest fundamentals.

Optogalvanic spectroscopy of the C"5Pi ui-A' 5Sigma+g electronic system of N2.

We have recorded spectra involving the 3-1, 4-2, 2-0, and 2-2 bands of the C" 5Pi(ui)-A' (5)Sigma+(g) electronic system of N(2) using optogalvanic detection in a discharge through a supersonic jet expansion of argon mixed with a trace of nitrogen gas. The spectra have an effective rotational temperature of about 45 K. They involve all five spin-orbit components of the C" 5Pi(ui) state, which has allowed for precise determination of the spin-orbit coupling in this state.

The spin-orbit and rotational constants for the N2 C" 5Pi(ui) (v = 3) state.

The spin-orbit (A = -16.4 cm(-1)) and rotational (B = 1.017 cm(-1)) constants for the N2 C" 5Pi(ui)(v = 3) level are determined by a fit to rotational lines in the C" 5Pi(u)-A' 5Sigma(g)+(3-1) band that terminate in J'Omega' = 3(3), 4(3), 3(2), and 4(2) levels of the C" state.

Experimental determination of a spin-orbit interval in the C" 5Pi(ui) state of 14N2.

We have developed an experimental setup using the combination of laser optogalvanic detection and a supersonic expansion of excited N2 to record the high resolution spectrum of the (3-1) and (4-2) Herman infrared bands (C" 5Pi(ui)-A' 5Sigma(g)+). We report the first experimental determination of a spin-orbit interval (about 24 cm(-1)) in the C" 5Pi(ui) state of N2 for both the (3-1) and (4-2) vibrational bands as well as the first observation of the v' = 4 vibrational level.

A laser spectroscopic study of the X2pi(g), A2pi(u), and B2sigma+ states of BS2: Renner-Teller, spin-orbit, and K-resonance effects.

The lowest-lying vibronic levels of the X, A, and B states of BS2 have been investigated at high resolution using a combination of room-temperature absorption and supersonic jet data. In both cases, the BS2 radical was prepared in an electric discharge using a precursor gas mixture of BCl3,CS2, and either helium or argon. Extensive absorption spectra were obtained for the 0(0)0 and 2(1)1 bands of the A2pi(u)-X2pi(g) electronic transition in the visible.

New Rydberg-Rydberg Transitions of the ArH and ArD Molecules.

We report observations and analyses of bands in the spectra of the ArH and ArD molecules due to emission from the 4f Rydberg complexes. For ArD, the observed bands are 4f --> 5s and 4f --> 3dlambda for all three components lambda = 0, 1, and 2 of the 3d state. These give direct information on all 14 spin-orbit components of the 4f complex.

New Rydberg-Rydberg Transitions of the ArH and ArD Molecules.

We report and rotationally analyze new spectra of the ArH and ArD molecules corresponding to the 0-0 vibrational bands of electronic transitions from the nd and ns states to the 4p Rydberg complex, in united atom notation. In ArD, our observation of the 3ddelta state, along with previous observations of the 3dpi and 3dsigma states, demonstrates that the components of the 3d state are widely separated and can be treated as Hund's case (b) states, unlike the components of the np and 4f states, which form closely coupled case (d) Rydberg complexes. The band 4dsigma --> 4p has also been assigned.

Lasing threshold reduction in grating-tuned cavities.

A new geometry for grating-tuned cavities that reduces optical losses from the gratings, lowers the lasing threshold, and enhances the laser output is described and tested. We achieved these enhancements by feeding back into the cavity light that is normally lost through grating reflections. The new geometry is tested on two grazing-incidence dye laser cavities: one that resembles a Littman -Metcalf design and demonstrates the essential principle of the new arrangement, and one that introduces modifications necessary to allow single-longitudinal-mode operation without mode hopping over a tuning range of ~15 cm-1 .