[Interactions of radiation factors and smoking in the etiology of lung cancer in workers of atomic enterprises].

It was shown on the basis of retrospective investigation of 500 workers at a nuclear enterprise (162 cases of lung cancer, 338 persons as matching control) that the interaction of external gamma-irradiation (> 2.0 Gy) and the body-burden of 239Pu (> 9.3 kBq) at lung cancer incidence in multiplicative.

[An evaluation of the role of radiation and nonradiation factors in the development of lung cancer in workers at a radiochemical enterprise (1)].

A case-control study using logistic regression included 500 employees of the nuclear works (162 patients with lung carcinoma and 338 healthy controls). After examination of radiation and nonradiation causative factors 5 proved statistically significant. For them the following chance proportions were obtained: smoking 6.

[Evaluation of the effects of biological and clinical factors on plutonium excretion in man].

The values of the natural urine excretion coefficient in 84 workers have been received. The observations were ranging from 1970 to 1984. To analyse this data the references about radiobiological, medical, anthropometrical and other factors which potentially influence osteotropic radionuclide excretion in man and animals have been studied.

[The "dose-response" mechanism of tumorigenesis in workers of radiochemical plants].

The "dose-response" mechanism has been studied for three main histological types of tumor in a cohort of 500 workers occupationally exposed to different doses of radiation (162 patients with lung cancer and 338 practically healthy persons) using the "case-control" method and multifactorial logic regression procedure. A non-linear threshold dependence was established for incorporated plutonium, with the threshold being at 8 kBq to correspond to 80 kGy. This relationship has been particularly distinct in cases of adenocarcinoma.

[Effect of radiation and other factors on the pathogenesis of various histologic types of lung cancer in workers of radiochemical plants].

Adenocarcinoma frequency in Pu incorporation-related lung cancer patients among plutonium workers was found to be 74% versus 33% in control. Each histological pattern of lung cancer appeared to be related to several etiological factors but in varying degree. Incorporated Pu proved the strongest factor in adenocarcinoma development.

[Evaluation of radiation and non-radiation factors in the development of lung cancer in radiochemical plant employees].

Five hundred workers of a nuclear facility (162 cases of lung cancer and 338 healthy subjects) were examined on a case-control basis using the logical regression method and 10 radiation and non-radiation factors. Five significant factors were identified. The following rick values were obtained for them: tobacco smoking-6.

[Localization of lung cancer in persons exposed to plutonium-239].

Pulmonary cancer site was studied in 131 workers engaged into radioactive chemicals production and 178 examinees of control group. All examinees died in 1965-1989. Incorporation of plutonium-239 increased the number of lower lobe pulmonary cancers (upper-0.

[Changes in the entropy of heart mass in dogs during inhalation of transuranic radionuclides].

Altogether 140 random-bred dogs of both sexes, aged 2 to 4 (body mass 14.5 +/- 0.1 kg) were examined.

[Haptoglobin phenotypes and serum enzyme activity].

Haptoglobin (Hp) phenotypes were determined by thin-layer polyacrylamide gel electrophoresis in 2071 normal Russians, Tatars, and Bashkirs. Hp phenotype distribution was found similar in these populations, making up 13.4% for Hp 1-1, 48% for Hp 1-2, 38.

[The medical sequelae of the radiation accident in the Southern Urals in 1957].

As a result of an accidental outburst of long-lived radionuclides at the nearest zone of the trace, a dose rate of gamma-radiation was several dozen CGy/h and in the open country at some populated areas it was 0.1 CGy/h. The evacuation of 10730 persons permitted a decrease of possible radiation doses 2-24-fold.

[Serum alkaline phosphatase and gamma-glutamyltranspeptidase in metastatic malignant tumors].

Levels of gamma-glutamyltranspeptidase and total, alpha 2 and alpha 1-alkaline phosphatase versus dissemination pattern and survival time were studied in patients with stage III and IV tumors of various sites. No significant changes in the activity of the said enzymes were registered in cases of single hepatic metastasis and metastasis-free liver. A slight increase in the enzymes' activity was observed in patients with pronounced liver involvement within months 10-4 before death.

[Blood serum creatine kinase in diseases of the cardiovascular system].

Serum creatine-kinase activity was above the upper normal limit in 40-80% of the 632 patients admitted to hospital for angina pectoris and deteriorating essential hypertension. The highest (4-6-fold) increase over the mean control values was associated with myocardial ischemia, paroxysmal tachycardia and hypertensive crises. Intramuscular injections were shown to be unrelated to increased incidence or magnitude of creatine-kinase activation in the examined patients.

[Assessment of the results of serum enzyme studies in different forms of myocardial infarction].

An examination of 400 coronary patients demonstrated a relationship between increased serum CPK, AST, LDH and LDH-1, and the spread and severity of myocardial infarction (MI). In transmural and large-focal MI, CPK activity peak observed on Day 1-2 of the disease was increased 4-12-fold, and that of AST, 5-fold, as compared to the upper limit of the normal range. In small-focal and subendocardial MIs, the increase was 1.