[Moyamoya disease].

Moya-moya is a rare cerebrovascular disease characterized by the progressive occlusion of cerebral vessels with partial switching off the circle of Willis and arteries that feed it. The article provides a review of literature, modern diagnostic criteria and a description of a single clinical case. The onset of the disease in this patient was characterized by headache and speech disorders.

[Tension type headache: GABA-ergic drug anvifen efficacy].

Objective: To assess the efficacy of aminophenylbutyric acid (anvifen), a synthetic GABA-receptor agonist, in the treatment of adult patients with tension type headache (TTH).

Material And Methods: Eighty-seven patients with episodic TTH (ETTH) and 30 patients with chronic TTH (CTTH) were examined. The area under the headache curve, sleep quality, the Hospital Anxiety and Depression Scale (HADS) scores and stress resistance measured by an original questionnaire were evaluated.

Characterization of the antibiotic compound no. 70 produced by Streptomyces sp. IMV-70.

We describe the actinomycete strain IMV-70 isolated from the soils of Kazakhstan, which produces potent antibiotics with high levels of antibacterial activity. After the research of its morphological, chemotaxonomic, and cultural characteristics, the strain with potential to be developed further as a novel class of antibiotics with chemotherapeutics potential was identified as Streptomyces sp. IMV-70.

Apolipoprotein A-I possessing activity of defensin proteins modifies structure of plasma membranes.

We studied the in vitro effect of apolipoprotein A-I possessing activity of defensin proteins on the structure of plasma membranes in donor erythrocytes and lymphocytes. Incubation of erythrocyte membranes with apolipoprotein A-I was accompanied by significant changes in biophysical characteristics of a fluorescent probe pyrene in the hydrophobic membrane region and a decrease in Na+/K(+)-ATPase activity. Microviscosity of annular lipids in the plasma membrane of lymphocytes increased during incubation with apolipoprotein A-I.

Molecular mechanisms of changes in TNF-alpha production by blood mononuclears in chronic viral hepatitis C.

Chronic viral hepatitis C is associated with decreased production of TNF-alpha by the peripheral blood mononuclear leukocytes irrespective of virus genotype and degree of the morphological activity of the process in the liver. This process positively correlates with the increase in the content of TNF-alpha soluble receptor (molecular weight 55 kDa), which can play a role in the mechanisms of immunopathogenesis of long persistence of hepatitis C virus in the body.

[Hyperventilation syndrome in bronchial asthma, essential hypertension and organic neurosis. Clinical picture and external respiration function].

The external respiration function was studied in 100 patients with hyperventilation syndrome (HVS) divided into 3 groups: 40 patients with HVS and bronchial asthma (group 1) consisting of 15 males and 25 females (age median--45 years, 25 percentile--37 years, 75 percentile--53 years); 39 patients with HVS and essential hypertension (group 2) consisting of 8 males and 31 females (age median 49, 25 percentile--40 years, 75 percentile--57 years); 21 patients with HVS without concurrent somatic diseases of group 3 (7 males, 14 females, age median 45 years, 25 percentile--28 years, 75 percentile--45 years). It is shown that different disorders of pulmonary ventilation correspond to different clinical manifestations of HVS. Thus, in bronchial obstruction (group 1) HVS manifests with "weak respiration", in restrictive pulmonary disorders (group 2) HVS manifests as "heavy respiration", in high parameters of bronchial permeability (group 3)--"shallow respiration".

["Hematological masks" of chronic viral hepatitis].

Aim: To reveal the structural features of the red blood cell membrane in patients with prolonged persistence of hepatitis B virus (HBV) and hepatitis C virus (HCV).

Materials And Methods: 61 patients with moderate and mild chronic viral hepatitis B and C were examined. A control group comprised 22 healthy donors.

Fluorescent probing of lymphocyte and erythrocyte plasma membranes in persistence of tick-borne encephalitis virus: monitoring of structural changes.

The structure of lymphocyte and erythrocyte plasma membrane in patients with long persistence of tick-borne encephalitis virus was studied using fluorescent probes pyrene and 1-anilinonaphthalene-8-sulfonate. The authors analyze the clear-cut disorders in the membranes of both lymphocytes and erythrocytes in viral tick-borne-encephalitis from the viewpoint of generalized involvement of cell membranes in infectious process.

Structural and functional characteristics of lymphocytes in chronic carriers of tick-borne encephalitis virus.

Study of the surface phenotype, structure of plasma membrane, and activity of DNA repair system in peripheral blood lymphocytes from patients with different clinical forms of tick-borne encephalitis associated with long persistence of the virus revealed a pronounced imbalance between lymphocyte subpopulations, increased microviscosity of the plasma membrane lipid phase, and decreased activity of the DNA repair system in lymphocytes.

[Identification of Zygowillopsis californica strains of various origin by polymerase chain reaction with universal primers].

After reevaluation of the taxonomic position of 27 yeast collection strains of different origin by UP-PCR followed by dot-hybridization, only 22 strains were assigned to the biological species Zygowilliopsis californica (Lodder) Kudriavzev. Four strains were identified as Williopsis suaveolens (Klöcker) Naumov et al. Universal primers L45 and N21 are recommended for identification of the Z.

[Williopsis saturnus and Williopsis beijerinckii-different taxons from polymerase chain reaction data with nonspecific primers].

Fifteen strains of the yeast Williopsis sensu stricto were analyzed by means of UP-PCR. With the N21 universal primer, this approach showed that the strains could be clearly divided into two groups corresponding to the species W. saturnus (Klöcker) Zender and W.

[Molecular-genetic analysis of the yeast Komagataea (williopsis) pratensis populations from Caucasian and Tien Shan regions].

The analysis of sixteen Komagataea (Williopsis) pratensis from the Caucasian and Tien Shan soils by the PCR, blot hybridization, and isoenzyme electrophoresis techniques showed that fifteen of them do belong to the species K. pratensis. The isolates from the two geographic areas differed in some physiological characteristics and in the PCR product profiles obtained with the microsatellite primers (CAC)5 and (GACA)4.

[Discrimination of the soil yeast species Williopsis saturnus and Williopsis suaveolens by the polymerase chain reaction using nonspecific primers].

Thirty-five yeast strains of the genus Williopsis, analyzed by the polymerase chain reaction with the universal primer N21, were found to belong to two sibling species, W. saturnus and W. suaveolens.

[A novel antibiotic of the aureolic acid group. Isolation, physicochemical and biological properties, identification].

An antibiotic complex was extracted from the culture fluid of Streptomyces phaeofaciens, strain 51. By the physicochemical properties it was referred to the group of aureolic acid. The complex was separated to chromatographically pure components by column chromatography.

[Clinico-psychopathologic and somato-autonomic studies of functional hyperthermia in adolescents].

In a non-psychiatric clinic a combined psychiatric and somato-autonomic investigation was performed in 75 prepuberty and puberty children with functional hyperthermia . Syndromal and nosological characterization was performed on a spectrum of psychic disorders in these patients. Some correlations were found between syndromal and nosological distributions and grouping based on somato-autonomic++ picture.

Eremomycin--new glycopeptide antibiotic: chemical properties and structure.

By a combination of chemical and spectroscopic (1H and 13C NMR) studies the structure of a glycopeptide antibiotic eremomycin has been elucidated. It is closely related to vancomycin, but differs in sugar and chlorine content. The eremomycin aglycone contains monodechlorovancomycinic acid; the only chlorine atom is situated in the second amino acid after the N-terminal amino acid residue of the peptide.

[The structure of eremomycin, a new antibiotic of the group of polycyclic glycopeptides].

Structure of the carbohydrate moiety of the eremomycin molecule was assessed. Two residues of eremosamine were detected in the antibiotic. One of them in the composition of 2-0-(L-eremosaminyl)-D-glucopyrazone dissaccharide was linked by the phenol group to monodechlorvancomycinic acid and the other formed the monosaccharide branch by the alcohol group of the same acid at the peptide C-end area.

[Psychoautonomic syndrome in non-infectious subfebrile conditions in children].

To ascertain the cerebral organization and the importance of its specific levels in the occurrence of the thermopathological syndrome associated with vegetovascular dystonia, 40 children aged 8-15 years with non-infectious subfebrile conditions of long standing were examined. The children's status was marked by polysystemic shifts common to the neurogenous disorders. Of crucial significance was dysfunction of the structures of the suprasegmental level (the limbic-reticular complex) of vegetative regulation with the involvement of the specialized hypothalamic centers of thermoregulation, with excessive sympathetic influences at the periphery and formation of the psychovegetative syndrome.

[Structure of eremosamine--an amino sugar from the antibiotic eremomycin].

A new amino sugar named eremosamine was isolated from hydrolysate of eremomycin, an antibiotic belonging to the group of polycyclic glycopeptides. Crystalline derivatives of the amino sugar i. e.

[The structure of the aglycon of eremomycin--a new antibiotic of the polycyclic glycopeptide group].

Eremomycin is shown to be a new representative of the group of polycyclic glycopeptides. By the amino acid composition it is close to vancomycin but by the structure of triphenoxytriaminotricarboxylic acid it differs from vancomycin. Monodechlorovancomycinic acid was detected in eremomycin.

[Carbohydrate linkage with the peptide portion of the ristomycin A molecule].

The mannose monosaccharide residue in ristomycin A is bound via C-3 phenolic oxygen of the 1,2,3,5-substituted ring with actinoidinic amino acid. The tetrassacharide branch is attached to the only phenolic oxygen of triaminotricarboxylic acid. The ristosaminyl residue is linked via one of the two aliphatic hydroxyl groups of the same amino acid.

[Revision of the structure of ristomycinic and actinoidinic amino acids].

The structures of ristomycin and actinoidine amino acids described earlier were revised. Crystalline derivatives of the amino acids and the products of their oxidation were prepared. The study on the spectral properties of the compounds showed that ristomycin and actinoidine amino acids had the structures of 3-(2'-hydroxy-5'-glycyl-phenoxy)-4-methyl-5-hydroxyphenylglycine and 2-(2'-hydroxy-5'-glycyl-phenyl)-3,5-dioxyphenylglycine respectively.

[Triaminotricarboxylic amino acid oxidation productions of actinoidin and ristomycin].

Aromatic acids with three benzene nuclei bound through oxygen were obtained from actinoidin and ristomycin on their oxydation with permanganates of methylated aglycones and peptides. The structures of the methyl esters of these acids were determined by spectral methods. They are the following: methyl-3,5-bis-(4-methoxycarbonyl-phenoxy)-4-methoxybenzoate (from ristomycin) and methyl-3-(2-chlor-4-methoxycarbonyl-phenoxy)-5-(4-methoxycarbonyl-phenoxy)-4-methoxybenzoate (from actinoidin).