Publications by authors named "Toka Tharwat"
Article Synopsis
- * Non-selective NSAIDs can cause gastrointestinal issues and kidney damage due to their effect on both COX-1 and COX-2, while selective COX-2 inhibitors aim to reduce inflammation with fewer side effects on the stomach.
- * Recent studies focus on developing new compounds that selectively target COX-2, offering safety benefits but also raising concerns about potential cardiovascular risks.
Two innovative series derived from nicotinic acid scaffold were synthesized and evaluated for their anti-inflammatory activity. Ibuprofen, celecoxib and indomethacin were used as standard drugs. All the newly synthesized compounds were in vitro screened for their anti-inflammatory activity adopting 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide dye (MTT), as well as Griess assays.
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