"Salt and Pepper Endothelium" Recurring After Descemet Membrane Endothelial Keratoplasty.

Purpose: To describe the presence of "salt and pepper endothelium", that is, typical cellular inclusion bodies in a patient with Fuchs endothelial corneal dystrophy (FECD), that recurred in the donor corneal endothelial cells after Descemet membrane endothelial keratoplasty (DMEK).

Methods: A 76-year-old man underwent DMEK for FECD in his left eye. Routine specular microscopy imaging, best-corrected visual acuity measurements, and pachymetry measurements were performed before and after surgery.

Fully automatic evaluation of the corneal endothelium from in vivo confocal microscopy.

Background: Manual and semi-automatic analyses of images, acquired in vivo by confocal microscopy, are often used to determine the quality of corneal endothelium in the human eye. These procedures are highly time consuming. Here, we present two fully automatic methods to analyze and quantify corneal endothelium imaged by in vivo white light slit-scanning confocal microscopy.

Self-limiting corneal edema with multiple parallel lines on the endothelium (SCEMPLE).

The purpose of this study was to report the natural course and in vivo confocal microscopy (IVCM) findings of five cases with unilateral self-limiting corneal edema and multiple parallel lines on the endothelium (SCEMPLE). This study is an observational case series. Five patients, who experienced a blurred vision due to SCEMPLE, were studied using slit-lamp examination and white-light IVCM (Confoscan 4; Nidek Technologies, Padova, Italy).

Cataract surgery in patients with Fuchs' endothelial corneal dystrophy: when to consider a triple procedure.

Purpose: To ascertain preoperative and intraoperative factors that predict the need for endothelial keratoplasty (EK) in patients with Fuchs' endothelial corneal dystrophy (FECD) undergoing cataract surgery.

Design: Prospective, observational cohort study.

Participants: Eighty-nine patients (89 eyes) with FECD who require cataract surgery.

Monitoring the inflammatory process in herpetic stromal keratitis: the role of in vivo confocal microscopy.

Purpose: To investigate the role of in vivo confocal microscopy (IVCM) in the detection of inflammatory activity and follow-up of herpetic stromal keratitis (HSK).

Design: Prospective observational cohort study.

Participants: Thirty-eight patients with active HSK.

How normal is the transparent cornea? Effects of aging on corneal morphology.

Purpose: To ascertain the effects of aging on corneal morphology and to illustrate the morphologic diversity of the different layers in the normal cornea as seen by in vivo confocal microscopy (IVCM).

Design: Observational cross-sectional study.

Participants: A total of 150 healthy subjects, evenly distributed over 5 age categories, comprising 75 men and 75 women.

Descemet stripping automated endothelial keratoplasty: effect of intraoperative lenticule thickness on visual outcome and endothelial cell density.

Purpose: To determine the correlation between the intraoperative donor lenticule thickness in Descemet stripping automated endothelial keratoplasty (DSAEK) and both the best-corrected visual acuity (BCVA) and endothelial cell density (ECD) at 6 months. To describe relevant surgical considerations with regard to the choice of microkeratome head.

Design: Prospective case series.

Normative database for corneal backscatter analysis by in vivo confocal microscopy.

Purpose: To ascertain the sex and age relatedness, diurnal variation, and repeatability of backscatter measurement in the normal human cornea.

Methods: Seven corneal backscatter variants were measured by in vivo confocal microscopy (IVCM) in both normal eyes (n = 314) of 157 healthy subjects. These subjects were assigned to one or more of three groups.

Long-term follow-up of hydrogel intracorneal lenses in 2 aphakic eyes.

We report the outcome of hydrogel intracorneal lens implantation in 2 patients. The lenses were implanted at approximately 50% depth in the cornea to correct high hyperopic refractive errors of 10.5 diopters (D) and 14.

Wide-range calibration of corneal backscatter analysis by in vivo confocal microscopy.

Purpose: To report intra- and interinstrument calibration methods for corneal backscatter analysis by in vivo confocal microscopy.

Methods: Applicability of two reference standards was evaluated for corneal backscatter calibration. Repeated measurements of four concentrations of AMCO Clear (GFS Chemicals, Inc.

Zipper cell endotheliopathy: a new subset of idiopathic corneal edema.

Purpose: To report the clinical and histologic findings of a new subset of idiopathic corneal edema: zipper cell endotheliopathy.

Design: Observational case report.

Participant: A 55-year-old woman with unilateral bullous keratopathy.

Endothelial involvement in herpes simplex virus keratitis: an in vivo confocal microscopy study.

Purpose: To describe the appearance, frequency, and clinical consequences of corneal endothelial involvement in human herpes simplex virus (HSV) keratitis as seen by in vivo confocal microscopy (IVCM).

Design: Prospective observational case series.

Participants: A total of 285 patients with HSV keratitis who visited the cornea department of the Rotterdam Eye Hospital between May 2005 and May 2008.

Graft insertion during Descemet-stripping automated endothelial keratoplasty: pulling the graft inward.

We describe a technique to facilitate insertion of the folded donor graft during Descemet-stripping automated endothelial keratoplasty (DSAEK). Surgery is performed using a standard technique, and the graft is pulled into the anterior chamber using a double-armed 10-0 polypropylene suture with straight 16 mm needles. The technique of pulling the graft inside the anterior chamber is easy and ensures that the graft is inserted and unfolded in the right direction.