Oral administration of candesartan improves the survival of mice with viral myocarditis through modification of cardiac adiponectin expression.

Purpose: We examined the effects of the angiotensin II receptor type 1 blocker candesartan on myocarditis injury in a murine model of acute myocarditis. We hypothesized that candesartan improves cardiac damage by inducing cardiac expression of adiponectin.

Methods And Results: We examined changes in heart failure caused by myocarditis in mice by candesartan based on induction of cardiac adiponectin expression.