Adverse Drug Reactions to Antiretroviral Therapy: Frequency, Type, and Risk Factors in Children in Mali.

Objective: The aim of our study was to evaluate the frequency, type, and risk factors associated with adverse drug reactions (ADRs) in HIV-positive children with adherence to antiretroviral therapy (ART) at the Unit of Care and Accompaniment for People Living With HIV (USAC) of Bamako.

Methods: A cross-sectional study was conducted at USAC of Bamako from May 1, 2014, to July 31, 2015. We included children aged 1 to 14 years with at least 6 months of ARV treatment initiated at USAC, with or without ADRs.

[Knowledges And Practices Of Iron Prescription By The Pediatric Ward In CHU Gabriel Touré Of Bamako, Mali].

Goal: To assess knowledges and practices on iron prescription in pediatric ward in CHU Gabriel Touré of Bamako, Mali.

Tools And Methods: It was a prospective and transversal study canied out. We submitted questionnaire and analyzed the case history of to the children aged 1-60 months old who received iron during the study period from 1 to 30 July 2012.

Excision in girls: Life-threatening acute complications in girls within 7 days of excision: Experience of the Pediatric Department of the University Hospital Gabriel Toure in Bamako, Mali.

Unlabelled: The practice of excision in girls poses a significant risk to their health. The objective of this study was to determine the immediate acute complications associated with this practice.

Patients And Methods: This was a retrospective descriptive study over a period of 15 months including all girls aged 0-15 years hospitalized for acute complications related to excision within 7 days of the practice in the pediatric department of the University Hospital Gabriel Toure.

[Particularities of early neonatal bacterial infection in the hospital environment of the CHU Gabriel Touré in Bamako].

Introduction: Early neonatal bacterial infection (ENBI) is a major concern in neonatology. In Mali, no study had addressed this aspect, hence the initiation of this work to study the epidemiological-clinical, biological and bacteriological profile of ENBI.

Materials And Methods: This was a descriptive longitudinal study that took place from june 27 to september 3, 2016 involving newborns aged ≤ 72 hours hospitalized for ENBI confirmed by blood culture in the neonatology service of the pediatrics department of the Center Hospitalier et Universitaire (CHU) Gabriel Toure in Bamako.

[Knowledges And Practices Of Iron Prescription By The Pediatric Ward In CHU Gabriel Touré Of Bamako, Mali].

Goal: To assess knowledges and practices on iron prescription in pediatric ward in CHU Gabriel Touré of Bamako, Mali.

Tools And Methods: It was a prospective and transversal study canied out. We submitted questionnaire and analyzed the case history of to the children aged 1-60 months old who received iron during the study period from 1to 30 July 2012.

[Portal cavernoma at child about two observations].

We report two observations of portal cavernoma diagnosed successively in Bamako and Dakar. The first is a 6-year-old male admitted to the service for ascites and abdominal pain. At admission the clinical parameters (weight, height, temperature, cranial perimeter and temperature) were within the norms for age.

Precursor B-cell acute lymphoblastic leukaemia-a global view.

As haematologists, we always seek to follow standardised guidelines for practice and apply the best treatment within our means for our patients with blood diseases. However, treatment can never follow an exact recipe. Opinions differ as to the best approach; sometimes more than one treatment approach results in identical outcomes, or treatments differ only by the manner in which they fail.

[Socio-demographic, clinical, and therapeutic aspects of adolescents treated and followed for HIV infection at the Hospital Gabriel Toure paediatric center].

Unlabelled: HIV infection is a chronic infectious disease requiring long-term management and regular follow-up of patients.

Objectives: The aims of this study was to describe the socio-demographic, clinical, biological and therapeutic aspects of adolescents treated and followed for HIV infection at the Hospital Gabriel Toure paediatric center.

Patients And Methods: From 01/01/2001 to 31/12/2017, the medical records of children followed for HIV infection until adolescence were analyzed.

[Management of patients with Covid 19: analysis of prescription drugs at Gabriel Touré University Hospital].

Unlabelled: COVID-19 was declared a pandemic in March 2020. For case management, Mali has created several treatment sites including the site of the CHU Gabriel Touré.

Aims: The objective of the study was to analyse drug prescriptions for the COVID-19 treatment at the CHU Gabriel Touré.

[Management of Acute Malnutrition in Children in a Sahelian Secondary Hospital].

Unlabelled: Malnutrition among children under five is a major public health problem in low-income countries, and contributes significantly to mortality in this age group. The purpose of this work was to evaluate the epidemiological and clinical profile of malnourished children at the Nara hospital in north of Mali.

Method: It was a retrospective and descriptive study, from 01/01/2016 to 31/12/2016.

Childhood brain tumors in Mali.

to assess epidemiologic and clinical aspects of childhood brain tumors in Mali. a retrospective, descriptive study of children aged 0-15 years with brain tumors, conducted in the pediatrics department of the Gabriel Touré University Hospital Center in Bamako, Mali, from January 31, 2007 to December 3, 2012. In all, 41 cases of brain tumors were recorded during this period (mean: 5.

[Accidental household poisoning of the child at the Gabriel Toure university hospital center in Bamako].

Introduction: Household accidental child poisonings are frequent pediatric medical emergencies in developing countries.

Objective: To study the epidemiological, etiological, clinical and therapeutic aspects of acute accidental domestic poisoning in children aged 0 to 15 years admitted to the pediatric emergency department of Gabriel Toure.

Method: This was a prospective, descriptive study that ran from January 1, 2014 to December 31, 2014.

Treatment of retinoblastoma in Sub-Saharan Africa: Experience of the paediatric oncology unit at Gabriel Toure Teaching Hospital and the Institute of African Tropical Ophthalmology, Bamako, Mali.

Background: Retinoblastoma (Rb) is the most common intraocular primary malignancy in children. In industrialised countries, the cure rate is about 95%. We present the results of a prospective study on the management of Rb in the paediatric oncology unit of Gabriel Touré Teaching Hospital and African Institute of Tropical Ophthalmology, from November 1, 2011 to December 31, 2015.

[Congenital Hypothyroidism: 2 observed cases at the Gabriel Toure University Hospital of Bamako, Mali].

We report two observations of congenital hypothyroidism diagnosed in 2011 in the university hospital of Gabriel Toure in Bamako. The first occurred in a male infant of 40 days, admitted for respiratory distress and anterior compressive cervical swelling. Although his neonatal period occurred without any medical particularity, family medical history revealed the presence of unexplored goiter in three paternal uncles.

[Knowledge and practices regarding iron prescription by medical staff of the pediatric ward in the Gabriel Touré university hospital of Bamako, Mali].

Goal: To assess knowledge and practices on iron prescription in the pediatric ward of the Gabriel Touré university hospital of Bamako, Mali.

Material And Methods: A cross-sectional study was carried out from the 1st to 31st July 2012 in the service. We presented the participants with a questionnaire and analyzed the medical files of children aged 1-60 months old who received an iron prescription.

[National reference unit of neonatology: state of play].

Background: The neonatal mortality rate in Mali is one of the highest in the world. Only one national reference neonatology unit is available in the country.

Aim: To describe the time-course of morbidity, mortality, staff and accommodation facilities from 2008 to 2009 in Mali's unique national reference neonatology unit.

[Epidemiology and prognosis of childhood cancers at Gabriel-Touré Teaching Hospital (Bamako, Mali)].

Unlabelled: Cancer today is being treated as a public health problem in Africa, as in developed countries.

Objective: The aim of this retrospective study was to evaluate the epidemiology and outcome of children treated in the Pediatric Oncology Unit of Gabriel Touré Teaching Hospital in Bamako (Mali), six years after it opened.

Methods: Retrospective study of the files of all children aged 15 and younger diagnosed with cancer and treated by chemotherapy between January 1, 2005, and December 31, 2010.

[Mothers knowledges, attitudes and practices on female genital excision in Bamako].

Aim: In Mali society, female excision is a cultural practice. Despite the awareness campaigns, it affects nearly 85% of the female population (EDSM IV). This study was initiated to assess the knowledges, attitudes and practices of mothers about female circumcision.

Preliminary evaluation of children treated with metronomic chemotherapy and valproic acid in a low-income country: Metro-Mali-02.

Background: Metronomics is defined by the combination of metronomic chemotherapy and drug repositioning. Since off-patent chemotherapeutic drugs can be used and given the low toxicity profile of this approach, metronomics appears to be an invaluable alternative to bring affordable targeted therapies in low-income countries.

Objective: The aim of this study was to report on the preliminary efficacy and safety of a metronomic vincristine/cyclophosphamide/methotrexate/valproic acid regimen given to children with refractory cancer of various tumor types or with a very advanced disease.

Adverse drug reactions to antiretroviral therapy: prospective study in children in sikasso (mali).

Objectives: Adverse events during antiretroviral treatment are frequent and various. Their diagnosis incurs some various difficulties according to the geographic context. Our aim was to describe the frequency, nature, and preventability of adverse drug reactions (ADRs) due to antiretroviral treatment in Malian outpatient children.

[Retinoblastoma: inventory in Mali and program to develop early diagnosis, treatments and rehabilitation].

Retinoblastoma (RB) is a rare embryonic tumour that represents 1/16,000 births in France. In Mali, a study showed the characteristics of a hospital series of cases seen in Bamako in the Pediatric Oncology Unit of Gabriel Touré Teaching Hospital and in the Tropical Ophthalmology Institute of Africa (IOTA) between January 2005 and June 2007. Median age was 4 years versus 2 years in France for unilateral disease.

[Reasons for hospitalisation of hiv-infected children in pediatric service of the Gabriel Toure teaching hospital, Bamako].

Purpose: The aim of our study was to determine the reasons of hospitalization of HIV-infected children in our context and to identify factors associated with mortality in the course of hospitalization.

Patients And Method: Our study took place in the department of pediatrics of the Gabriel Touré Teaching Hospital. It involved all the children hospitalized between March 1st and August 31st, 2010 to whom an infection with HIV was diagnosed before or during the hospitalization.