Relationship between Sputum Bacterial Load and Lung Function in Children with Cystic Fibrosis Receiving Tobramycin.

Background: Chronic pulmonary infection with pathogens such as Pseudomonas aeruginosa is associated with lung function decline and increased mortality in people with cystic fibrosis (CF). The relationship between sputum bacterial load and the severity of pulmonary exacerbations remains unclear. This study aimed to explore the relationship between sputum bacterial load and clinical response to antibiotic treatment of pulmonary exacerbations in children with CF.

Outcomes of holmium: YAG laser vs. Thulium fiber laser for ureteric stones during ureterorenoscopic lithotripsy - a prospective, randomized single-centre study.

Introduction: The use of lasers has created a major impact in the management of stones. The aim of our study is to evaluate and compare the effectiveness and safety profile of Thulium fiber laser (TFL) and Holmium: YAG (Ho: YAG) laser in ureteric stones.

Methods: It is a prospective randomized single-centre study carried out from December 2022 to December 2023.

Advances in the Synthetic Utility of Difluorocarbene Generated from TMSCF (Ruppert-Prakash Reagent) and Its Derivatives.

Organofluorine compounds are of pivotal significance particularly, in drug and agrochemical industries and different strategies have been designed for their synthesis. The last two decades witnessed the emergence of difluorocarbene as an efficient synthetic tool, providing easy access to organofluorine compounds. This review summarises the reactions of difluorocarbene generated from Ruppert-Prakash reagent (TMSCF) and its derivatives TMSCFCl and TMSCFBr.

Trace metal contamination in core sediments of Pandharabodi Lake, Central India: eco-environmental implications.

Freshwater lakes in central India like Pandharabodi Lake (PBL), face escalating environmental pressures due to anthropogenic activities, threatening their ecological conditions. Despite growing concerns, systematic investigations on trace metal pollution in the PBL sediments are so far not done, hindering effective conservation strategies. The present study aims to evaluate temporal distribution, enrichment, and potential eco-environmental risks of 14 trace metals (Al, Fe, Mn, Zn, Cu, Cr, Ni, Pb, Co, U, V, Rb, Th, and Sc) in the PBL core sediments.

A review of urban heat island mapping approaches with a special emphasis on the Indian region.

With an estimated population of about 6 billion living in urban areas by 2050, controlling the rate of urbanization is one of the major challenges governments face in the twenty-first century. Increasing urbanization is problematic since it causes heat accumulation within urban areas due to the enhanced anthropogenic activities. With developing countries like India aiming for their economic growth, combating urban heat islands (UHIs) is a critical step in improving the quality of life.

Urinary Lipoarabinomannan (LAM) in HIV sero-negative miliary tuberculosis patients.

Background: Tuberculosis (TB) is the leading cause of death from infectious diseases worldwide next to COVID. Miliary presentation is a form of TB that can cause 100% mortality without treatment. Due to lack of a gold standard test, a systematic approach of high index of clinical suspicion and efforts at demonstrating Mycobacterium tuberculosis is imperative to early treatment initiation and mortality reduction.

Exploring the impact of herbaceous Apiaceae family plants on primary dysmenorrhea: a systematic review protocol.

Objectives: Primary dysmenorrhea is a leading cause of job and school absenteeism among young females. Despite its high prevalence, contemporary medicine offers limited treatment options. Herbaceous members of the Apiaceae family, such as L L L Mill.

The role of ancillary ligands on benzodipyridophenazine-based Ru(II)/Ir(III) complexes in dark and light toxicity against TNBC cells.

In this study, we investigated the impact of ancillary ligands on the anticancer activity of benzodipyridophenazine-based Ru(II) and Ir(III) complexes (Ru1, Ru2, Ir1, and Ir2). These metal complexes displayed three significant absorption bands attributed to the ligand-centered (LC) transitions, ligand-to-ligand charge transfer (LLCT), and metal-to-ligand charge transfer (MLCT). Binding studies of biomolecules were performed with the complexes along with the ligand, and it was found that after binding with Ru(II)/Ir(III), the properties of the ligands were enhanced.

seeds capped calcium oxide nano particles - anti-microbial, antioxidant, anti-ulcer analysis.

Calcium Oxide (CaO) is the best replica of logically plentiful earth metal oxides. CaO nanoparticles include sphere-shaped or faceted elevated surface area and magnetic nanostructured particles. The current study give the information regarding booming synthesis of calcium oxide nanoparticles using calcium chloride as precursor and seed extract as capping agent.

Malignant pleural mesothelioma.

Malignant pleural mesothelioma is a rare and aggressive tumour of the pleura, commonly linked to asbestos exposure. However, its diagnosis is challenging, especially without known exposure. We present the case of a woman in her early 70s with no history of asbestos exposure, who presented with progressive breathlessness and left-sided chest pain.

Poly(vinyl alcohol) Nanocomposites Reinforced with CuO Nanoparticles Extracted by : Evaluation of Wound-Healing Applications.

This study focused on the synthesis of plant-mediated copper-oxide nanoparticles (OsCuONPs) via the sol-gel technique and the fabrication of OsCuONP-infused PVA composite films (POsCuONPs) utilizing the solvent casting method for wound-healing applications. The prepared OsCuONPs and nanocomposite films were characterized using UV-visible spectra, FTIR, SEM, XRD, TGA, water contact-angle (WCA) measurements, and a Universal testing machine (UTM) for mechanical property measurements. The UV and FTIR tests showed that OsCuONPs were formed and were present in the PVA composite film.

Characterizing the mono- and triacylglycerol lipase (MAGL and TAGL) genes from pearl millet (Pennisetum glaucum L.) and elucidating their dynamics with biochemical traits linked with rancidity.

We cloned two variants of lipase gene-MAGL and TAGL from pearl millet. Lipase showed negative correlation with antioxidants and total phenolics. FAA can be used as marker for rancidity.

Stability analysis of elastomeric impression materials after antimicrobial disinfection.

Impression materials used for replication of dental structures frequently come into touch with blood and saliva during the impression operation. Hence, disinfection of impression mistrials is needed. Therefore, it is of interest to evaluate the effects of three different disinfectants on the antibacterial activity and dimensional stability of the elastomeric impression material.

An anatomico-morphometric analysis of proximal femur.

The proximal femur is an important area of interest as it is involved in the articulation of the hip joint and it contributes to the mechanics of locomotion and the weight bearing capacity of the femur. Pathologies like osteoporosis and fractures are common in this site, and surgical interventions like hip arthroplasty and internal fixtures with implants rely on knowledge about the anatomy of the proximal femur to ensure effective treatment. Hence, a greater understanding of these variations will be helpful in constructing better fitted prosthesis.

Identification of serotype O3b and high-risk clone ST37 of revealed by comparative genomic analysis.

Background: Epidemiological risk factors such as the demography of a place, environment, food, livestock, and companion animals are known sources of infection. Whole-genome sequencing (WGS) has become a powerful tool to complement traditional microbiological characterization of foodborne pathogens. Moreover, has several species complexes (KpSC) and is very difficult to differentiate using routine microbiological methods.

Small-Diameter Stents in Cardiovascular Applications.

Small-diameter stents play a crucial role in treating congenital heart diseases and variety of vascular conditions that have application from paediatrics to geriatric conditions, and a comprehensive review in this direction is lacking. This review explores historical development, design innovations, material compositions and mechanistic insights into functions of small-diameter stents, with a specific emphasis on biodegradable options. The necessity for stents that can adapt to growth of paediatric patients is discussed, highlighting the transition from durable polymers to bioresorbable materials such as polylactic acid (PLA) and magnesium alloys.

Enhancing urban air quality prediction using time-based-spatial forecasting framework.

Air quality forecasting plays a pivotal role in environmental management, public health and urban planning. This research presents a comprehensive approach for forecasting the Air Quality Index (AQI). The proposed Time-Based-Spatial (TBS) forecasting framework is integrated with spatial and temporal information using machine learning techniques on data collected from a wide range of cities.

Foreign object debris detection in lane images using deep learning methodology.

Background: Foreign object debris (FOD) is an unwanted substance that damages vehicular systems, most commonly the wheels of vehicles. In airport runways, these foreign objects can damage the wheels or internal systems of planes, potentially leading to flight crashes. Surveys indicate that FOD-related damage costs over $4 billion annually, affecting airlines, airport tenants, and passengers.

Unravelling the aromatic symphony: redirecting bifunctional mushroom synthases towards linalool monofunctionality.

Enzymes are the cornerstone of biocatalysis, biosynthesis and synthetic biology. However, their applicability is often limited by low substrate selectivity. A prime example is the bifunctional linalool/nerolidol synthase (LNS) that can use both geranyl diphosphate (GPP) and farnesyl diphosphate (FPP) to produce linalool and nerolidol, respectively.

Selenium-based nanomaterials: green and conventional synthesis methods, applications, and advances in dye degradation.

The rapidly expanding industrialization and global increase in economic activities have drawn attention to the concerning accumulation of waste. The textile industry plays a significant role in environmental pollution, especially in and water pollution. Harmful dyes used during the fabrication process are mixed with water bodies through sewage or wastewater ejected from industrial factories.

Efficacy of Bacillus clausii UBBC-07 and Bacillus coagulans Unique IS-2 in Mitigating Pulmonary Parameters in Patients With Moderate COVID-19 Symptoms.

Probiotics have shown efficacy in preventing and reducing infections caused by common viruses, including rotavirus, norovirus, hepatitis, human papillomavirus (HPV), human immunodeficiency virus (HIV), and herpes simplex virus (HSV). A randomized, double-blind, placebo-controlled, three-arm parallel-group study was conducted on 56 patients with moderate COVID-19 symptoms. Patients were randomly assigned to one of the three groups: standard treatment combined with UBBC-07, standard treatment combined with Unique IS-2, or standard treatment with a placebo.

Hereditary colorectal cancer syndromes and inflammatory bowel disease: results from a registry-based study.

Purpose: In this study, we investigated the progression of high-grade dysplasia (HGD)/CRC in patients with hereditary colorectal cancer syndromes (HCSS) and concomitant inflammatory bowel diseases (IBDs).

Methods: We described the natural history of a series of patients with confirmed diagnosis of hereditary colorectal cancer syndromes (HCCSs) and concomitant IBDs who were referred to the Hereditary Digestive Tumors Registry at the Fondazione IRCCS Istituto Nazionale dei Tumori of Milan.

Results: Between January 1989 and April 2024, among 450 patients with APC-associated polyposis and 1050 patients with Lynch syndrome (LS), we identified six patients with IBDs (five with UC, one with ileal penetrating CD) and concomitant HCCSs (five with LS, one with APC-associated polyposis).

Elevating performance and interpretability of in silico classifiers for drug proarrhythmia risk evaluations using multi-biomarker approach with ranking algorithm.

Background And Objective: Using electrophysiological simulations and machine learning to predict drug proarrhythmia risk has gained popularity due to its effectiveness. The leading in silico drug assessment system mainly uses a single biomarker (qNet) to predict proarrhythmia risk, offering good performance and straightforward interpretation. Other advanced classifiers incorporating additional physiological biomarkers provide better predictive capabilities but are less intuitive.

Artificial Neural Network-Based Validation, DFT, Thermal and Biological Evaluation of 4-Aminoantipyrine-Derived Ru(III) Complexes.

New methodologies have been evaluated for validating analytical characterization with artificial neural networks (ANNs). Compared to previous machine learning models, these provide more accurate and automated results with high testing accuracy. The Schiff base ruthenium complexes used in the proposed study were synthesized using 4-aminoantipyrine derivatives.