Publications by authors named "Todd V Meyer"
Background: The 2022 outbreak of the clade IIb monkeypox virus and subsequent global spread lead to an urgent need for the development of high-throughput, sensitive, and reproducible diagnostic tests.
Methods: We developed 3 assays to detect monkeypox virus, 2 (MPXV+ and MPXV) for m2000 RealTime and 1 (MPXV) for Alinity m platforms. Dual targets in E9L and B6R (MPXV+) and J2L and B7R (MPXV) increased mutation resistance.
Article Synopsis
- Scientists studied a virus called Bangui virus, which is carried by insects and can cause diseases in humans, especially in places like the Democratic Republic of the Congo.
- They used a special technique called metagenomic next-generation sequencing (mNGS) on blood samples from HIV-positive people to find out if there were other viruses present.
- The Bangui virus is very rare in humans because it mainly lives in birds and insects, which makes it hard for the virus to spread to people.
Molecular surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is growing in west Africa, especially in the Republic of Senegal. Here, we present a molecular epidemiology study of the early waves of SARS-CoV-2 infections in this country based on Bayesian phylogeographic approaches. Whereas the first wave in mid-2020 was characterized by a significant diversification of lineages and predominance of B.
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- The Abbott Global Surveillance program is monitoring the ability of various diagnostic tests to detect different circulating variants of SARS-CoV-2, including major variants of concern like alpha, beta, gamma, and delta.
- A study was conducted using live virus cultures and clinical samples, testing numerous Abbott assays for their effectiveness in identifying these variants.
- Results showed that all molecular assays successfully detected 100% of variant patient specimens, while antigen tests also performed well, confirming the reliability of Abbott's diagnostics against ongoing viral diversity.
Picobirnaviruses (PBV) are found in a wide range of hosts and typically associated with gastrointestinal infections in immunocompromised individuals. Here, a divergent PBV genome was assembled from a patient hospitalized for acute respiratory illness (ARI) in Colombia. The RdRp protein branched with sequences previously reported in patients with ARI from Cambodia and China.
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- * Researchers sequenced samples from the first two waves of the pandemic in Senegal, identifying new combinations of spike mutations that were unique to the second wave.
- * The findings reveal ongoing local diversification of the virus and suggest that different lineages may be evolving escape mutations simultaneously.