Publications by authors named "Todd Hunter"

Article Synopsis
  • Tarperprumig (ALXN1820) is a bispecific antibody designed to treat conditions caused by dysregulated activity in the complement alternative pathway, usable via small volume injections either under the skin or intravenously.
  • It consists of two variable domains that target properdin and human serum albumin, showing a high binding affinity and forming a stable complex.
  • The antibody effectively inhibits key processes related to complement pathway activation and is currently undergoing clinical development for relevant disorders.
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Unlabelled: Sport-related concussions (SRCs) are multi-faceted injuries requiring coordinated care for return-to-play (RTP). Although the number of concussions in collegiate football is increasing annually, there is poor standardization among RTP protocols. Recent evidence suggests there is an increased risk of lower extremity injury, neuropsychiatric consequences, and re-injury after SRC, and risk factors for a prolonged recovery from SRC have also been identified.

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The rotational spectrum of the most stable conformer of ethylene glycol (HO(CH)OH) has been recorded between 360-890 GHz using a frequency-modulation submillimeter spectrometer. The refinement and extension of the spectroscopic parameters over previous efforts provide predicted catalog frequencies for ethylene glycol with sufficient accuracy for comparison to high-frequency astronomical data. The improvement in the cataloged line positions, and the need for improved accuracy enabled by high-frequency laboratory work, is demonstrated by an analysis of ethylene glycol emission at 890 GHz in the high-mass star-forming region NGC 6334I in ALMA Band 10 observations.

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The processes leading to the birth of low-mass stars such as our Sun have been well studied, but the formation of high-mass (over eight times the Sun's mass, M(o)) stars remains poorly understood. Recent studies suggest that high-mass stars may form through accretion of material from a circumstellar disk, in essentially the same way as low-mass stars form, rather than through the merging of several low-mass stars. There is as yet, however, no conclusive evidence.

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