Publications by authors named "Toby Dunne"
Article Synopsis
- Mating pheromones activate GPCRs (Ste2 and Ste3) in yeast, promoting growth for mating, but this process is energy-intensive, leading to a hypothesis about nutrient deprivation's role in suppressing mating signals.
- Nutrient starvation causes the loss of Ste2 from the plasma membrane, with findings suggesting that TORC1 signaling is responsible for this effect, impacting mating signaling and other yeast GPCRs.
- The study identifies that both autophagy and TORC2-Ypk1 signaling act to downregulate the mating pathway, showing that TOR complexes play a crucial role in balancing pheromone signaling during nutrient stress.
The majority of existing models for predicting disease risk in response to climate change are empirical. These models exploit correlations between historical data, rather than explicitly describing relationships between cause and response variables. Therefore, they are unsuitable for capturing impacts beyond historically observed variability and have limited ability to guide interventions.
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