Publications by authors named "Toby Aarons"
Article Synopsis
- - Small extracellular vesicles (sEVs) play a key role in cell communication by transporting proteins, lipids, and nucleic acids, which can be non-invasively utilized as disease biomarkers due to their ability to cross barriers like the blood-brain barrier.
- - The study developed a method to isolate sEVs from small quantities of frozen human brain tissue using size exclusion chromatography after obtaining ethical approval and following a series of enzymatic and filtration steps.
- - The effectiveness of the isolation technique was confirmed through various analyses, revealing a good RNA yield for further studies, including qPCR and small RNA sequencing, enhancing the potential for diagnosing diseases using sEVs from brain tissue.
Exposure to inflammatory stressors during fetal development is a major risk factor for neurodevelopmental disorders (NDDs) in adult offspring. Maternal immune activation (MIA), induced by infection, causes an acute increase in pro-inflammatory cytokines which can increase the risk for NDDs directly by inducing placental and fetal brain inflammation, or indirectly through affecting maternal care behaviours thereby affecting postnatal brain development. Which of these two potential mechanisms dominates in increasing offspring risk for NDDs remains unclear.
View Article and Find Full Text PDFBackground: Brain-derived neurotrophic factor (BDNF) is essential for neurogenesis and has been implicated in Alzheimer's disease (AD). However, few studies have investigated together the epigenetic, transcriptional, and translational regulation of this peptide in the brain in relation to AD.
Objective: To investigate mechanisms underlying how BDNF is possibly dysregulated in the brain in relation to aging and AD neuropathology.