Publications by authors named "Tobias R Zahn"
Article Synopsis
- Timely re-epithelialization is crucial in burn care to prevent complications like infections and scarring, highlighting the need for effective topical treatments to speed up healing.
- Preliminary studies suggest that betulin, derived from birch bark, can enhance wound healing for conditions such as second degree burns and skin graft donor sites.
- A phase III clinical trial with 219 participants showed that a topical betulin gel (TBG) significantly accelerated wound closure compared to standard treatment, with faster healing times and mild, manageable side effects.
Although the exact etiology of Alzheimer's disease (AD) is a topic of debate, the consensus is that the accumulation of beta-amyloid (Abeta) peptides in the senile plaques is one of the hallmarks of the progression of the disease. The Abeta peptide is formed by the amyloidogenic cleavage of the amyloid precursor protein (APP) by beta- and gamma-secretases. The endocytic system has been implicated in the cleavages leading to the formation of Abeta.
View Article and Find Full Text PDFWe have developed a model system in Caenorhabditis elegans to perform genetic and molecular analysis of peptidergic neurotransmission using green fluorescent protein (GFP)-tagged IDA-1. IDA-1 represents the nematode ortholog of the transmembrane proteins ICA512 and phogrin that are localized to dense core secretory vesicles (DCVs) of mammalian neuroendocrine tissues. IDA-1::GFP was expressed in a small subset of neurons and present in both axonal and dendritic extensions, where it was localized to small mobile vesicular elements that at the ultrastructural level corresponded to 50 nm electron-dense objects in the neuronal processes.
View Article and Find Full Text PDF