Publications by authors named "Tobias M Freilinger"
Migraine and major depressive disorder (MDD) are common brain disorders that frequently co-occur. Despite epidemiological evidence that migraine and MDD share a genetic basis, their overlap at the molecular genetic level has not been thoroughly investigated. Using single-nucleotide polymorphism (SNP) and gene-based analysis of genome-wide association study (GWAS) genotype data, we found significant genetic overlap across the two disorders.
View Article and Find Full Text PDFMigraine is a recurrent pain condition traditionally viewed as a neurovascular disorder, but little is known of its vascular basis. In epidemiological studies migraine is associated with an increased risk of cardiovascular disease, including coronary artery disease (CAD), suggesting shared pathogenic mechanisms. This study aimed to determine the genetic overlap between migraine and CAD, and to identify shared genetic risk loci, utilizing a conditional false discovery rate approach and data from two large-scale genome-wide association studies (GWAS) of CAD (C4D, 15,420 cases, 15,062 controls; CARDIoGRAM, 22,233 cases, 64,762 controls) and one of migraine (22,120 cases, 91,284 controls).
View Article and Find Full Text PDFArticle Synopsis
- Migraine affects about 14% of the global population, yet its underlying molecular mechanisms are not well understood, triggering a debate on whether it stems from vascular or neuronal dysfunction.
- A genetic study involving nearly 60,000 migraine sufferers and over 316,000 controls identified 44 new single-nucleotide polymorphisms (SNPs) linked to migraine risk, with 28 of these loci being newly discovered.
- The research suggests a strong connection between the identified genetic loci and genes expressed in vascular tissues, supporting the theory that migraine may primarily involve vascular issues.
Objectives: Our goal was to assess the prevalence of complicated American Heart Association (AHA) lesion type VI plaques in the carotid arteries of patients with cryptogenic stroke.
Background: In up to 40% of ischemic stroke patients, no definite cause can be established despite extensive workup (i.e.