Publications by authors named "Tobias Kautz"
Article Synopsis
- MAIT cells, which recognize the vitamin B2 intermediate 5-OP-RU, are found in the kidneys of both humans and mice, though their specific role in kidney diseases remains unclear.
- A study shows that a unique subset of MAIT cells, resembling tissue-resident MAIT17 cells, increases during crescentic glomerulonephritis (cGN) and also appears in kidney biopsies from affected patients.
- The presence of these MAIT17 cells helps to suppress cGN through the expression of anti-inflammatory markers, suggesting they could be targeted for new anti-inflammatory treatments.
Article Synopsis
- The study investigates the differences between NK cells from the liver and those from peripheral blood in the context of liver inflammation and cirrhosis.
- Researchers analyzed samples from patients undergoing liver transplantation or resections, finding that cirrhotic livers contained a distinct type of NK cells, specifically enriched for CD49a+.
- This CD49a+ NK cell subset showed potential for high growth in vitro when exposed to low levels of IL-2, indicating their functional significance in the diseased liver environment.
Immune responses show a high degree of tissue specificity shaped by factors influencing tissue egress and retention of immune cells. The transcription factor Hobit was recently shown to regulate tissue-residency in mice. Whether Hobit acts in a similar capacity in humans remains unknown.
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