Publications by authors named "Tobias Kalin"
Article Synopsis
- Researchers studied the impact of mRNA SARS-CoV-2 vaccines on patients with autoimmune liver diseases to see if vaccination worsened their conditions.
- A total of 49 patients with primary biliary cholangitis (PBC), 35 with autoimmune hepatitis (AIH), and 9 with primary sclerosing cholangitis (PSC) were tested for autoantibodies before and after vaccination, with results indicating higher rates of autoantibody positivity in liver disease patients compared to healthcare workers.
- Despite some fluctuations in autoantibody levels following vaccination, the study concluded that mRNA vaccines do not cause significant short-term worsening of autoimmunity in these patients.
The basic structure of linearly anellated lapacho quinones, naphtho[2,3-b]furan-4,9-dione (7), was modified in the search for novel agents against keratinocyte hyperproliferation. The synthesis and structure-activity relationships of several heterocycle-fused naphthoquinones as well as a full range of 2- and 7-substituted derivatives of one of these, 8-hydroxynaphtho[2,3-b]thiophene-4,9-dione (8a), are described. Out of a total of 71 analogues, particularly 2-thenoyl-substituted 26l, 2-nicotinoyl-substituted 26m, and 2-oxadiazole-substituted 35a compared favorably with the antipsoriatic agent anthralin.
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