The differential diagnosis of tiredness: a systematic review.

Background: Tiredness is one of the most frequent complaints in primary care. Although often self-limiting and frequently associated with psychosocial stress, patients but also their physicians are often uncertain regarding a serious cause and appropriate diagnostic work-up. We conducted a systematic review and meta-analysis of studies reporting on differential diagnosis of fatigue in primary care.

Causes of chest pain in primary care--a systematic review and meta-analysis.

Aim: To investigate the frequencies of different and relevant underlying etiologies of chest pain in general practice.

Methods: We systematically searched PubMed and EMBASE. Two reviewers independently rated the eligibility of publications and assessed the risk of bias of included studies.

Studies of the symptom abdominal pain--a systematic review and meta-analysis.

Background: Diagnostic reasoning in primary care patients with abdominal pain is a complex challenge for GPs. To ensure evidence-based decision making for this symptom, GPs need setting-specific knowledge about the prevalence, potential risks for diseases and chance of recovery or risk of undesirable courses of disease.

Aim: We conducted a systematic review of symptom-evaluating studies on prevalence, aetiology or prognosis of abdominal pain.