Polymer drug conjugates containing memantine, tacrine and cinnamic acid: promising nanotherapeutics for the treatment of Alzheimer's disease.

Aim: To prepare polymer-drug conjugates containing a combination of memantine, tacrine, and )--(3-aminopropyl)cinnamide, promising therapeutics for the treatment of neurodegenerative disorders.

Methods: The conjugates were characterised by HNMR, particle size analysis, SEM, LC-MS, TEM/EDX, and XRD, followed by anti-acetylcholinesterase and drug release studies.

Results: H NMR analysis revealed successful drug conjugation with drug mass percentages in the range of 1.

Nanoparticles Loaded with Platinum Drugs for Colorectal Cancer Therapy.

Colorectal cancer is a common cancer in both men and women. Numerous studies on the therapeutic effectiveness of nanoparticles against colorectal cancer have been reported. Platinum treatments as well as other medications comprising of nanoparticles have been utilized.

Efficacy of Polymer-Based Nanomedicine for the Treatment of Brain Cancer.

Malignant brain tumor is a life-threatening disease with a low survival rate. The therapies available for the treatment of brain tumor is limited by poor uptake via the blood-brain barrier. The challenges with the chemotherapeutics used for the treatment of brain tumors are poor distribution, drug toxicity, and their inability to pass via the blood-brain barrier, etc.

Design and Efficacy of Nanogels Formulations for Intranasal Administration.

Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influenza, meningitis, pneumonia and as veterinary vaccine carriers for the protection of animals from encephalomyelitis and mouth to foot disease.

Quinoline-Based Hybrid Compounds with Antimalarial Activity.

The application of quinoline-based compounds for the treatment of malaria infections is hampered by drug resistance. Drug resistance has led to the combination of quinolines with other classes of antimalarials resulting in enhanced therapeutic outcomes. However, the combination of antimalarials is limited by drug-drug interactions.