[The pathological mechanisms of the intermenstrual pain syndrome].

Comprehensive clinicophysiological examinations of 80 patients suffering from the intermenstrual pain syndrome revealed organic changes in the pelvic organs of 92.5% of women and disturbances in the central structures participating in the conduction and control of pain sensitivity and vasomotor regulation in all the examinees, these changes correlating with specific vegetovascular and psychoemotional disorders. Three pathogenetic variants of development of this syndrome were defined.

[Effects of sex hormones on systemic reactions of the brain in women of different age].

Comparative analysis of electroencephalograms (EEG) and brain reactions to single and rhythmic photostimulation in 40 girls aged 9 to 17 with ovarian aplasia or hypofunction, 39 women of a reproductive age with ovarian exhaustion, and in 305 experimental animals aged 2 to 60 days with changed levels of estrogenic hormones showed that such changes influenced the formation of cerebral response starting from the age of 14-15 in humans and from days 15-20 in animals. The general trend of the electrical activity of the brain in hormonal deficiency manifested in all the groups by changed function of the activating brain structures. An increase of estrogen level at the age of 14-15 (in girls) and 20-30 days (in animals) caused the appearance of convulsive activity on the background EEG and an increase of rhythmic discharges of afteraction in the evoked potential.

[The efficacy of the dispensary observation of patients with ischemic heart disease who live in a rural locality].

30 patients with chronic ischemic heart disease allocated to controlled treatment and close monitoring, and 30 patients with ischemic heart disease placed under routine dispensary observation, living in rural areas, were examined. Effectiveness of dispensary follow-up of the IHD patients was found to be dependent upon three factors: use of differentiated approach to prescription of drugs, continuity of work in organization of treatment and feasibility of giving therapy under carefully health monitored conditions.

[Autonomic nervous system activity during the normal menstrual cycle].

Body adaptation reactions to changes of the internal conditions (neurohumoral shifts related to ovulation and corpus luteum development) were studied in 15 women of a reproductive age with normal biphasic cycle in the early follicular and medium lutein phases on the basis of mathematical analysis of heart rhythm, a number of cardiovascular and respiratory system parameters, and brain electric activity. Moderate tension of the regulatory mechanisms in the lutein phase of the cycle was protective and adaptive and probably related to body preparation to a would-be pregnancy. These adaptive effects are different in different women: in some internal environment parameters vary within a wide spectrum, in others these parameters show a trend to retain their functioning regimen.

[Use of thermovision examination in hand burns].

With the use of thermovision set TVT-01 "Raduga" 17 healthy persons (control group) and 40 injured persons with the burn of various degree of severity were examined. In superficial I-II degree burn on the hand the temperature within the centre of injury exceeds normal level by 1.6-2 degrees C, and III A degree--by 2.

[The pathogenetic mechanisms of hyperthermia in patients with the premenstrual syndrome].

Functional status of the central and autonomic nervous system was analyzed in 28 patients with the premenstrual syndrome one of whose manifestations was disordered thermoregulation. The examinations were carried out during both cycle phases. Analysis of the EEG data and clinical findings has shown different patterns of autonomic thermoregulation disturbances in three groups of patients and permitted the authors to suggest that changed activity of certain neurotransmitter systems connected with hormonal secretion over the course of the cycle was responsible for these disturbances.

[The late clinical and physiological effects of different methods for the surgical treatment of patients with a uterine leiomyoma].

Electroencephalographic studies and mathematical analysis of heart rhythm have shown that reconstructive plastic surgery is a more sparing and physiologic method as against supravaginal amputation of the uterus, providing normal functioning of all the body systems in late periods after surgery.

[Cerebrovascular circulation in patients with oligomenorrhea].

Brain hemodynamics was studied in 76 patients with oligomenorrhea aged 18 to 35 from the data of rheoencephalography. Disorders of the regional tone of brain vessels were different and related to the time of the menstrual cycle disorder; this may be explained by the degree of changes in various neuromediator mechanisms of brain circulation and reproductive system function regulation.

[General principles of the pathogenesis of vegetovascular and psychoemotional disorders during menstrual cycle and methodological approaches to their study].

Analysis of charts filled in by 79 women (mean age 31.5 +/- 4.0 years) over the course of 2-3 menstrual cycles has demonstrated the regular manifestation of various psychosomatovegetative symptoms over the entire course of the cycle (in the follicular, lutein phases, and during ovulation).

[Prediction of the severity of the course of a pathologic process at various stages of burns using phytolectins].

To predict the course of a pathological process in burn patients, the possibility for using the agglutinative capacity of erythrocytes caused by presence of lectins in the aqueous-saline extracts of the 12 species of drug plants permitted for use in medicine was studied. The activity of lectins was judged about by the intensity of agglutination of erythrocytes in 21 donor and in 26 patients with III-IV degree burns at different stages of the disease. A significant decrease in total agglutinative activity of erythrocytes in burn convalescents as compared with that in healthy patients was established.

[Characteristics of the functional state of different sections of the autonomic nervous system and their role in the pathogenesis of oligomenorrhea].

Analysis of the clinical picture of oligomenorrhea and of the results of studies of the function of various sections of the autonomic nervous system (ANS) in 58 patients of a reproductive age has revealed differences in these functions, related to the time of menstrual disorders onset. Oligomenorrhea patients with menarche complained of cardiovascular, respiratory, and emotional-motivational disorders, examinations have revealed in them dysfunctional disorders and reduced reserve potentials of both ANS sections. In oligomenorrhea patients in whom the condition developed at the age of 18-25 after a period of regular menstruations the effects of various stress factors resulted in reduction of the functional activity of the ergotropic (sympathoadrenal) section of the ANS.

[Characteristics of the functional state of the central nervous system in women during the menstrual cycle and in premenstrual syndrome].

Electroencephalographic examination of the function of the central nervous system in 30 healthy women and in 15 ones suffering from the premenstrual syndrome, carried out over both phases of the menstrual cycle, has revealed clear-cut differences between the two groups. 46% of the patients developed pathologic shifts at the level of the brain stem, 37% of the hypothalamic level, and 17% combined involvement of these portions of the brain. Triggering of the compensatory defense mechanisms already during the follicular phase of the cycle indicates failure of the adaptation mechanisms in the patients with the premenstrual syndrome.

[Folic acid in the combined treatment of patients with disseminated sclerosis and chronic gastritis].

Folic acid was used for the complex treatment of patients with multiple sclerosis. The doses employed were 200-300 mcg daily. It was established that folic acid improved the reparative processes in the gastric mucosa and produced a pronounced therapeutic effect on the neurological status of the patients, favoured improvement of their general condition.

[The hypothalamo-hypophyseal system in resistant ovary syndrome].

The study has been done in 30 women with the resistant ovary syndrome diagnosed by laparoscopy, laparotomy and histologic examination of ovarian biopsy samples. Genetic study identified the feminine phenotype and genotype (46,XX). Estradiol levels corresponded to those seen in the follicular menstrual phase, prolactin levels were normal, and gonadotropin levels were above basal values and were several fold above the ovulatory peak, when tested with luteinizing hormone-releasing factor in 7 patients and after estrogen challenge in 5 patients.

[The reaction of the hypophysis to thyroliberin and metoclopramide in women with hyperprolactinemia].

Functional tests with i.v. injection of metoclopramide (10 mg) and thyroliberin (200 micrograms) with a record of PRL and TSH levels for 120 min.

[Hypothyroidism and hyperprolactinemia].

Blood thyrotropic hormone, thyroxin, tri-iodothyronine, FSH, LH, estradiol and progesterone levels were examined in 14 patients with primary hypothyroidism and 11 normal women of reproductive age. All the women under study were subjected to functional tests with intravenous thyroliberin (TRH) and metoclopramide. All hypothyroid patients had anovulatory infertility.