Erratum: Functionalized MoS Nanosheets as Multi-Gene Delivery Vehicles for Pancreatic Cancer Therapy: Erratum.

[This corrects the article DOI: 10.7150/ntno.27308.

Recent Advances in Optical Fiber Enabled Radiation Sensors.

Optical fibers are being widely utilized as radiation sensors and dosimeters. Benefiting from the rapidly growing optical fiber manufacturing and material engineering, advanced optical fibers have evolved significantly by using functional structures and materials, promoting their detection accuracy and usage scenarios as radiation sensors. This paper summarizes the current development of optical fiber-based radiation sensors.

Inorganic Thermoelectric Fibers: A Review of Materials, Fabrication Methods, and Applications.

Thermoelectric technology can directly harvest the waste heat into electricity, which is a promising field of green and sustainable energy. In this aspect, flexible thermoelectrics (FTE) such as wearable fabrics, smart biosensing, and biomedical electronics offer a variety of applications. Since the nanofibers are one of the important constructions of FTE, inorganic thermoelectric fibers are focused on here due to their excellent thermoelectric performance and acceptable flexibility.

Special Issue "Fiber Optic Sensors and Applications": An Overview.

We present here the recent advance in exploring new detection mechanisms, materials, processes, and applications of fiber optic sensors.

Hybrid Plasmonic Fiber-Optic Sensors.

With the increasing demand of achieving comprehensive perception in every aspect of life, optical fibers have shown great potential in various applications due to their highly-sensitive, highly-integrated, flexible and real-time sensing capabilities. Among various sensing mechanisms, plasmonics based fiber-optic sensors provide remarkable sensitivity benefiting from their outstanding plasmon-matter interaction. Therefore, surface plasmon resonance (SPR) and localized SPR (LSPR)-based hybrid fiber-optic sensors have captured intensive research attention.

Carbon Allotrope-Based Optical Fibers for Environmental and Biological Sensing: A Review.

Recently, carbon allotropes have received tremendous research interest and paved a new avenue for optical fiber sensing technology. Carbon allotropes exhibit unique sensing properties such as large surface to volume ratios, biocompatibility, and they can serve as molecule enrichers. Meanwhile, optical fibers possess a high degree of surface modification versatility that enables the incorporation of carbon allotropes as the functional coating for a wide range of detection tasks.

An Integrated Sensor-Model Approach for Haptic Feedback of Flexible Endoscopic Robots.

Haptic feedback for flexible endoscopic surgical robots is challenging due to space constraints for sensors and shape-dependent force hysteresis of tendon-sheath mechanisms (TSMs). This paper proposes (1) a single-axis fiber Bragg grating (FBG)-based force sensor for a TSM of a robotic arm and (2) an integrated sensor-model approach to estimate forces on other TSMs of that arm. With a robust and simple structure, a temperature-compensated sensor can be mounted on the distal sheath to measure forces applied by the TSM.

Carbon Dot-functionalized Interferometric Optical Fiber Sensor for Detection of Ferric Ions in Biological Samples.

This work reports an interferometric optical microfiber sensor functionalized with nitrogen- and sulfur-codoped carbon dots (CDs) for the detection of ferric ions (Fe). Compared to other CD-based ferric ion sensors, the sensing mechanism of this presented sensor is dependent on the refractive index modulations due to selective Fe adsorption onto the CD binding sites at the tapered region. This is the first study in which CD-based sensing was performed at the solid phase as a chelator, which does not rely on its fluorescence properties.

An Advanced Hand-Held Microfiber-Based Sensor for Ultrasensitive Lead Ion Detection.

This study demonstrated a l-glutathione-modified nonadiabatic microfiber sensor to detect a trace level of heavy metal ions in aqueous solution. The sensor showed an exclusively selective response to Pb among other metal ions and a measured detection limit of 5 μg/L, lower than the maximum allowable limit of Pb in drinking water by the World Health Organization. Moreover, a novel compact all-fiber-based interrogation scheme was proposed to promote the development of a portable hand-held system for on-site measurement.

Functionalized MoS Nanosheets as Multi-Gene Delivery Vehicles for Pancreatic Cancer Therapy.

Transition metal dichalcogenides (TMDCs) are categorized as novel two-dimensional (2D) nanomaterials with unique physical and chemical properties, bearing varied applications in medical and materials sciences. However, only a few works report the application of TMDCs for gene therapy in cancer treatment. Here, we engineer a multi-gene delivery system based on functionalized monolayer MoS, which can co-deliver HDAC1 and KRAS small interfering RNAs (siRNAs) to Panc-1 cancer cells for combinational cancer therapy.

Birefringent Bragg Grating in C-Shaped Optical Fiber as a Temperature-Insensitive Refractometer.

We demonstrate a simple-to-fabricate refractometer based on the inscription of fiber Bragg gratings in a special C-shaped optical fiber. The C-shaped fiber was drawn into shape using a quarter cladding removed preform of a commercial standard single-mode fiber by simple machining. The sensor did not suffer from cross-sensitivity of the refractive index with ambient temperature fluctuations, commonly occurring with many optical fiber refractometers.

Functionalized Fiber End Superstructure Fiber Bragg Grating Refractive Index Sensor for Heavy Metal Ion Detection.

We present a novel superstructure fiber Bragg grating fiber end sensor capable of detecting variations in refractive index (RI) of liquids and potentially that of gases, and demonstrated an application in the detection of heavy metal ions in water. The sensor is capable of sensing RI variations in the range of 1.333 to 1.

Self-adaptive Bioinspired Hummingbird-wing Stimulated Triboelectric Nanogenerators.

Bio-inspired technologies have remarkable potential for energy harvesting from clean and sustainable energy sources. Inspired by the hummingbird-wing structure, we propose a shape-adaptive, lightweight triboelectric nanogenerator (TENG) designed to exploit the unique flutter mechanics of the hummingbird for small-scale wind energy harvesting. The flutter is confined between two surfaces for contact electrification upon oscillation.

A Self-Powered Implantable Drug-Delivery System Using Biokinetic Energy.

The first triboelectric-nanogenerator (TENG)-based self-powered implantable drug-delivery system is presented. Pumping flow rates from 5.3 to 40 µL min under different rotating speeds of the TENG are realized.

Biodegradable charged polyester-based vectors (BCPVs) as an efficient non-viral transfection nanoagent for gene knockdown of the BCR-ABL hybrid oncogene in a human chronic myeloid leukemia cell line.

First-line therapy of chronic myelogenous leukemia (CML) has always involved the use of BCR-ABL tyrosine-kinase inhibitors which is associated with an abnormal chromosome called Philadelphia chromosome. Although the overall survival rate has been improved by the current therapeutic regime, the presence of resistance has resulted in limited efficacy. In this study, an RNA interference (RNAi)-based therapeutic regime is proposed with the aim to knockdown the BCR-ABL hybrid oncogene using small interfering RNA (siRNA).

Fundus Photography in the 21st Century--A Review of Recent Technological Advances and Their Implications for Worldwide Healthcare.

Background: The introduction of fundus photography has impacted retinal imaging and retinal screening programs significantly.

Literature Review: Fundus cameras play a vital role in addressing the cause of preventive blindness. More attention is being turned to developing countries, where infrastructure and access to healthcare are limited.

RNAi-based therapeutic nanostrategy: IL-8 gene silencing in pancreatic cancer cells using gold nanorods delivery vehicles.

RNA interference (RNAi)-based gene silencing possesses great ability for therapeutic intervention in pancreatic cancer. Among various oncogene mutations, Interleukin-8 (IL-8) gene mutations are found to be overexpressed in many pancreatic cell lines. In this work, we demonstrate IL-8 gene silencing by employing an RNAi-based gene therapy approach and this is achieved by using gold nanorods (AuNRs) for efficient delivery of IL-8 small interfering RNA (siRNA) to the pancreatic cell lines of MiaPaCa-2 and Panc-1.

Simultaneous measurement of curvature and strain based on fiber Bragg grating in two-dimensional waveguide array fiber.

We report on the fabrication of a fiber Bragg grating (FBG) with multiple resonances in a two-dimensional waveguide array microstructured optical fiber containing 91 cores. Theoretical investigation reveals that these resonances originate from the identical and nonidentical mode couplings between forward-propagating and backward-propagating LP-like (m=1, 2, 3; LP refers to linearly polarized) supermodes. Since both the central wavelength and minimum transmission of these resonant dips respond differently to curvature and axial strain, this FBG can be applied in the simultaneous measurement of curvature and axial strain.

Highly sensitive refractive index sensor based on adiabatically tapered microfiber long period gratings.

We demonstrate a refractive index sensor based on a long period grating (LPG) inscribed in a special photosensitive microfiber with double-clad profile. The fiber is tapered gradually enough to ensure the adiabaticity of the fiber taper. In other words, the resulting insertion loss is sufficiently small.

Tunable microwave generation based on a dual-wavelength single-longitudinal-mode fiber laser using a phase-shifted grating on a triangular cantilever.

Frequency tunable microwave signal generation, based on a dual-wavelength single-longitudinal-mode (SLM) erbium-doped fiber (EDF) laser, incorporating a phase-shifted fiber Bragg grating (PS-FBG) with two π-phase shifts, is demonstrated. In the proposed configuration, the PS-FBG with two ultranarrow transmission bands is embedded in a triangular cantilever to serve as a wavelength spacing tunable filter with a fixed center wavelength by applying various strains on the cantilever. A section of unpumped EDF is employed as a saturable absorber to ensure SLM operation in each of the two lasing lines.

Switchable dual-wavelength single-longitudinal-mode erbium-doped fiber laser using an inverse-Gaussian apodized fiber Bragg grating filter and a low-gain semiconductor optical amplifier.

We present a stable and switchable dual-wavelength erbium-doped fiber laser. In the ring cavity, an inverse-Gaussian apodized fiber Bragg grating serves as an ultranarrow dual-wavelength passband filter, a semiconductor optical amplifier biased in the low-gain regime reduces the gain competition of the two wavelengths, and a feedback fiber loop acts as a mode filter to guarantee a stable single-longitudinal-mode operation. Two lasing lines with a wavelength separation of approximately 0.

Refractive index sensing based on higher-order mode reflection of a microfiber Bragg grating.

A fiber Bragg grating written in a photosensitive microfiber using KrF excimer laser via a uniform phase mask is demonstrated. We have successfully fabricated two Bragg gratings in microfibers having different diameters. In the reflection spectrum of a microfiber Bragg grating (MFBG), we observed two reflection peaks,which agrees with our numerical simulation results.

Simultaneous strain and temperature measurement using a compact photonic crystal fiber inter-modal interferometer and a fiber Bragg grating.

An all-fiber sensor scheme for simultaneous strain and temperature measurement is presented. The sensing head is formed by serially connecting a polarization maintaining photonic-crystal-fiber-based inter-modal interferometer (IMI) with a fiber Bragg grating (FBG). The IMI, exhibiting an opposite strain response as compared to that of the FBG, is highly sensitive to strain, while it is insensitive to temperature.

Analysis of inverse-Gaussian apodized fiber Bragg grating.

Inverse-Gaussian apodized fiber Bragg gratings (IGAFBGs) are numerically studied using the transfer matrix method and fabricated by the commonly used phase-mask scanning technique in a single-step scanning process. The IGAFBG can serve as a dual-wavelength passband filter, whose wavelength spacing can be continuously tuned by introducing a tunable chirp through applying a strain gradient in principle. Also, an IGAFBG with identical dual passbands having 0.

Inverse-Gaussian apodized fiber Bragg grating for dual-wavelength lasing.

A fiber Bragg grating (FBG) with an inverse-Gaussian apodization function is proposed and fabricated. It is shown that such a FBG possesses dual-wavelength narrow transmission peaks and the wavelength spacing between the two peaks is easily controllable during fabrication. Incorporating such a FBG filter into a fiber laser with a linear cavity, we obtain stable dual-wavelength emission with 0.