Publications by authors named "Tiziana Oliveto"
Brain functional impairment in beta-thalassaemia: the cognitive profile in Italian neurologically asymptomatic adult patients in comparison to the reported literature.
Immacolata Tartaglione Renzo Manara Martina Caiazza Pasquale Alessandro Carafa Violetta Caserta Tiziana Oliveto
Br J Haematol
August 2019
Article Synopsis
- A study examined cognitive function in 74 adult patients with beta-thalassaemia and 45 healthy controls, finding that patients had significantly lower Full-Scale Intelligence Quotient (FSIQ) scores compared to controls, even when adjusting for education levels.
- Non-transfusion-dependent patients showed a trend towards better cognitive performance than transfusion-dependent patients, yet both groups had similar cognitive profiles on specific tests.
- The study concluded that adults with beta-thalassaemia exhibit cognitive impairments and higher rates of psychological issues, which could lead to serious long-term socio-economic challenges.
Multi-factorial causes jeopardize brain integrity in β-thalassaemia. Intracranial parenchymal and vascular changes have been reported among young β-thalassaemia patients but conventional magnetic resonance imaging (MRI) findings are contradictory making early MRI and magnetic resonance angiography (MRA)/venography monitoring a matter of debate. This study prospectively investigated 75 neurologically asymptomatic β-thalassaemia patients (mean-age 35·2 ± 10·7 years; 52/75 transfusion-dependent; 41/75 splenectomised) using a 3T magnetic resonance scanner; clinical, laboratory and treatment data were also collected.
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