Publications by authors named "Tiziana Janner-Jametti"
Article Synopsis
- Some countries are changing their rules about blood donation because they believe the risk of a disease called variant Creutzfeldt-Jakob disease (vCJD) has decreased since it was a big concern in the past, especially in the UK.
- Experts held a meeting to talk about how to learn more about the disease and how to keep people safe during blood transfusions.
- They agreed that the risk of getting vCJD from blood donors who traveled or received blood in the UK is very low now, and it's important for experts in Europe to work together to create safer guidelines for blood donation.
Human bone marrow-derived mesenchymal stem cells (MSCs) have limited growth potential in vitro and cease to divide due to replicative senescence, which from a tissue-engineering perspective has practical implications, such as defining the correct starting points for differentiation and transplantation. Time spent in culture before the loss of required differentiation potential is different and reflects patient variability, which is a problem for cell expansion. This study aimed to develop a score set which can be used to quantify the senescent state of MSCs and predict whether cells preserve their ability to differentiate to osteogenic, adipogenic and chondrogenic phenotypes, based on colony-forming unit (CFU) assay, population doubling time (PDT), senescence-associated β-galactosidase (SA-β-Gal) activity, cell size, telomere length and gene expression of MSCs cultured in vitro over 11 passages.
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