Publications by authors named "Tiziana Caramico"
Vax2 is an eye-specific homeobox gene, the inactivation of which in mouse leads to alterations in the establishment of a proper dorsoventral eye axis during embryonic development. To dissect the molecular pathways in which Vax2 is involved, we performed a transcriptome analysis of Vax2(-/-) mice throughout the main stages of eye development. We found that some of the enzymes involved in retinoic acid (RA) metabolism in the eye show significant variations of their expression levels in mutant mice.
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- Natural antisense transcripts (NATs) are emerging as important regulators of gene expression, especially in eye development, where eight novel NATs related to transcription factors have been identified.
- These NATs interact with their corresponding sense genes, showing specific expression patterns in the retina and undergoing significant alternative splicing.
- Experimental findings indicate that NATs can influence the expression of their sense counterparts, suggesting their critical role in eye development and potentially in disease states.