Damage mechanisms of bisphenols on the quality of mammalian oocytes.

The extensive use of bisphenols in the plastics industry globally is a major growing concern for human health. Bisphenol compounds are easily leached out from plastic containers to food, beverages, and drinking water and contaminate the natural environment. Daily exposure of bisphenol compounds increases their load and impairs various organs, including the reproductive system.

Two-dimensional metal-organic frameworks (2D-MOFs) as a carrier for enzyme immobilization: A review on design and bio-applications.

In the realm of carriers for enzyme immobilization, the use of MOFs has accelerated owing to their exceptional porosity and stability. Among these, 2D metal-organic frameworks (2D-MOFs) have emerged as promising supports for enzyme immobilization. This review highlights advancements in their synthesis, structural properties, and functional characteristics, focusing on enhancing catalytic performance and stability.

Spin Polarization and Phase Transformation-Aided Efficient Overall Water Splitting Using NiMnGaCu Ferromagnetic Shape Memory Heusler Alloy.

We demonstrate experimentally that the combination of half-metallic property and shape memory features of the NiMnGaCu (NMGC) alloy can synergistically catalyze both the oxygen and hydrogen evolution reactions, leading to excellent water splitting. NMGC, a copper-doped nickel-based ferromagnetic shape memory alloy, undergoes first-order martensite to austenite phase transition with temperature variations. The martensite phase of NMGC demonstrates remarkable efficiency for both the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER).

Navigating healthcare leadership: Theories, challenges, and practical insights for the future.

Effective healthcare leadership is essential to ensure high-quality patient care and foster a supportive work environment for healthcare professionals. This review aims to consolidate existing healthcare leadership literature to provide evidence-based insights that can guide leadership development, improve team performance, and enhance patient care outcomes. A systematic search of academic databases such as PubMed, Scopus, Web of Science, CINAHL, Embase, and Google Scholar was performed using keywords related to healthcare leadership.

Grading of Knee Osteoarthritis Based on Kellgren-Lawrence Classification and Finding an Association Between Radiographic Features and Pain: A Cross-Sectional Study at a Tertiary Health Care Hospital.

: Osteoarthritis leads to painful joints, disability, restriction of ambulation, and reduces the person's ability to perform activities of daily living. Pain is one of the major symptoms of osteoarthritis. Some patients presented with severe pain while some with severe deformity.

Pickering Emulsions: Role of Particle Wettability and Adhesive Force on Droplet Bridging.

This study demonstrates the engineering of bridged Pickering emulsion (PE) gels by tuning the particle position at the interface and adhesive forces. This is achieved through controlled surface modification of hematite particles using oleic acid in a water-decane system. Microscopy observations revealed that the droplets are stabilized through a bridging mechanism, where oil droplets are connected by a shared monolayer of particles, with an intervening water layer between them.

Impact of the COVID-19 Pandemic on People with Dementia and their Caregivers: A Multiphase Observational Study from India.

Introduction: The COVID-19 pandemic has had multifaceted and enduring impacts on people with dementia and their caregivers; however, our understanding of the long-term outcomes remains limited. We aimed to explore the long-term effects of the COVID-19 pandemic on cognitive symptoms and vaccination rates in people living with dementia.

Method: This study was conducted as a part of a longitudinal study design in two specialized hospitals in South India.

Use of the Medtronic Hugo Robot-Assisted Surgery (RAS) System in Urogynecology: A Safety and Feasibility Study of the First 100 Procedures.

Introduction: This study evaluates the safety and feasibility of the Medtronic Hugo robot-assisted surgery (RAS) system in gynecological and urogynecological procedures. Through a retrospective analysis of prospectively collected data from the first 100 surgeries performed at Apollo Hospitals Chennai, we aim to provide insights into the system's effectiveness, including outcomes, complications, and overall surgical efficiency in major gynecological and urogynecological operations.

Methods: A single experienced robotic surgeon conducted the surgeries, including hysterectomies (n=66).

Harnessing Artificial Intelligence for Advancing Medical Manuscript Composition: Applications and Ethical Considerations.

Scientific medical manuscripts are fundamental to advancing research and enhancing patient care. With the emergence of artificial intelligence (AI), the process of composing such manuscripts has witnessed profound transformations. This review delves into the multifaceted role of AI in medical manuscript composition, analyzing its applications, benefits, drawbacks, and ethical implications.

Synthesis, characterisation of ZnO@PDA@Ag nanocomposite: Mechanistic interaction with BSA, photodegradation activity & in vitro cytotoxicity assay on H1299 lung cancer cell line.

Despite advancements in diagnosis and therapeutic, cancer retains to be a greatest cause of fatality and economic damage to the world. Metallic nanoparticles have grabbed attention particularly in the field of medicine attributed to their noteworthy biological and catalytic properties, offering significant progress. The work aimed to create a novel biocompatible 'Silver doped Polydopamine coated Zinc-Oxide nanocomposite' and investigate its efficacy in treating H1299 lung cancer cells as well as water remediation.

Considerations and Challenges to Develop Drug-drug Coamorphous System: A Recent Update.

Poor water solubility of several drugs, especially BCS class II and IV drugs, restricts their dissolution and negatively affects oral absorption. Amorphization of drugs is a year-old approach to enhance solubility and dissolution of poorly water-soluble drugs. Polymeric amorphous systems have been proven effective but have disadvantages, such as low drug loading, high carrier content, etc.

Non-motor symptoms in patients with Spinocerebellar ataxia type 12.

Introduction: Spinocerebellar ataxia type 12 (SCA12) is a rare autosomal dominant neurodegenerative disorder caused by abnormal CAG repeat expansion in the gene. This disease is classically characterized by action tremor, dysarthria, ataxia, and hyperreflexia. There are limited reports regarding the non-motor symptoms in patients with SCA 12.

Designing Impact Resistance and Robustness into Slippery Lubricant Infused Porous Surfaces.

Slippery lubricant infused porous surfaces (SLIPS) have the potential to address daunting challenges such as undesirable surface fouling/biofouling, icing, etc. However, the depletion of lubricants hampers their practical utility. As a solution, here a rational strategy is introduced that operates synergistically in three parts.

Novel antibodies detect nucleocytoplasmic O-fucose in protist pathogens, cellular slime molds, and plants.

Cellular adaptations to change often involve post-translational modifications of nuclear and cytoplasmic proteins. An example found in protists and plants is the modification of serine and threonine residues of dozens to hundreds of nucleocytoplasmic proteins with a single fucose (O-Fuc). A nucleocytoplasmic O-fucosyltransferase (OFT) occurs in the pathogen , the social amoeba , and higher plants, where it is called Spy because mutants have a spindly appearance.

Prevalence of Oral Potentially Malignant Lesions, Tobacco use, and Effect of Cessation Strategies among Solid Waste Management workers in Northern India: a pre-post intervention study.

Background: India bears the highest global burden of oral cancer, despite having an operational tobacco cessation framework. Occupational groups like solid waste management personnel face significant health challenges due to prevalent tobacco use, leading to oral potentially malignant lesions and oral cancer. Enhanced tobacco control strategies are essential for these groups.

Searching for the Holy Grail - Highly Potent Bridged Endoperoxides for Targeted Cancer Therapy.

The International Agency for Research on Cancer (IARC) recently estimated the global cancer burden in 2050. The statistics are startling, with a 77% hike and 35 million new cancer cases per year. The present discoveries have recommended plant-derived bridged endoperoxides or artemisinin-based semisynthetic analogues as safe, well-tolerated and powerful substitutes that could be effectively utilized as a warhead to fight against global enemies like cancer.

Infrared thermochromic antenna composite for self-adaptive thermoregulation.

Self-adaptive thermoregulation, the mechanism living organisms use to balance their temperature, holds great promise for decarbonizing cooling and heating processes. This functionality can be effectively emulated by engineering the thermal emissivity of materials to adapt to background temperature variations. Yet, solutions that marry large emissivity switching ( ) with scalability, cost-effectiveness, and design freedom are still lacking.

Glacial interglacial variations in the natural iron fertilization during the low sea ice periods along the eastern continental margin of Antarctica.

The Southern Ocean sequesters atmospheric CO through biological pumps, though its driving factors are debated. Modern productivity is regulated by natural iron fertilization from micronutrient influx through dust, regeneration, and Antarctic glaciers and sea ice melting (ice melt). The productivity along the eastern Antarctic continental margin was low during the last glacial period and gradually increased through the deglacial to Late Holocene, marked by distinct productivity peaks.

Analysis of Gillies Temporal Approach vs Towel Clip Method for Reduction of Zygoma Fractures.

Purpose: The purpose of this study was to analyse Gillies Temporal approach Vs Towel Clip method for reduction of zygoma fractures.

Method: A randomised comparative study was conducted on 30 patients having zygoma fractures confirmed with pre-operative NCCT face with 3 D reconstruction. Patients were divided into 2 groups, Group-1- Gillies temporal approach and Group-2- Towel clip method.