Processed Dietary Fiber Partially Hydrolyzed Guar Gum Increases Susceptibility to Colitis and Colon Tumorigenesis in Mice.

The vital role of naturally occurring dietary fibers (DFs) in maintaining intestinal health has fueled the incorporation of isolated DFs into processed foods. A select group of soluble DFs, such as partially hydrolyzed guar gum (Phgg), are being promoted as dietary supplements to meet recommended DF intake. However, the potential effects of regular consumption of these processed DFs on gastrointestinal health remain largely unknown.

Electric vehicles in transition: Opportunities, challenges, and research agenda - A systematic literature review.

This study conducts a systematic literature review on electric vehicle (EV) adoption, mapping critical themes and presenting an integrated framework to advance understanding of EVs' role in sustainable transportation. Drawing on 917 Scopus-indexed articles and 23 stakeholder interviews, it explores economic, environmental, energy, and social (EEES) dynamics through the Theory-Context-Methodology (TCM) framework and causal loop diagrams. Findings reveal dominant theories, such as the Theory of Planned Behavior and Value-Belief Norm Theory, and underscore the importance of methodological approaches like regression analysis and structural equation modeling.

Evaluating the efficacy of Lactobacillus acidophilus derived postbiotics on growth metrics, Health, and Gut Integrity in broiler chickens.

Continuous use of antibiotics in poultry feed as growth promoters poses a grave threat to humanity through the emergence of antibiotic resistance, necessitating the exploration of novel and sustainable alternatives. The present study was carried out to evaluate the performance of postbiotics derived from Lactobacillus acidophilus in broiler birds. The postbiotics were harvested by culturing probiotic bacteria from the stock cultures at the required temperature and duration under laboratory conditions and supplemented to broilers via feed.

Transcriptome profiling of Canine Parvovirus 2 Nonstructural gene 1(CPV2.NS1) transfected 4T1 mice mammary tumor cells to elucidate its oncolytic effects.

Oncolytic viral gene therapy is a directed approach to target cancer cells without affecting healthy cells of the body. Canine parvovirus (CPV2) is an oncolytic virus that precisely targets and destroys neoplastic cells by causing DNA damage, mitochondrial damage, and apoptosis. Non-structural gene 1 (NS1) of CPV, concerned with viral DNA replication is a key mediator of cytotoxicity of CPV and can specifically cause tumor cell lysis.

Jahn-Teller and pseudo-Jahn-Teller effects on the vibronic structure of the photoionized spectrum of cyanopropyne.

Nonadiabatic quantum dynamics are carried out to illustrate the photoionized spectrum of the cyanopropyne (CH3-C≡C-C≡N) as reported in recent experimental measurements [Lamarre et al., J. Mol.

Biological Reference Ranges for Healthy Indian Blood Donors: Experience of a Tertiary Care Center Vis-à-Vis International Literature.

Introduction: Complete blood count is the most common, basic test requisitioned in hematology. The normal reference ranges of hematological parameters are required owing to variable socioeconomic, environmental, and genetic factors in populations. The current study determines the reference ranges of the healthy Indian donor population of a high socioeconomic group.

Endogenous histidine peptides are physiological antioxidants that prevent oligodendrocyte cell death and myelin loss in vivo.

Histidine dipeptides (HDs) are synthesized in brain oligodendrocytes by carnosine synthase (carns1), but their role is unknown. Using metabolomics and in vivo experiments with both constitutive and oligodendrocyte-selective carns1-KO mouse models, we found that HDs are critical for oligodendrocyte survival and protect against oxidative stress. Carns1-KO mouse models had lower numbers of mature oligodendrocytes, increased lipid peroxidation, and behavioral changes.

Qualitative and quantitative reservoir characterization using seismic inversion based on particle swarm optimization and genetic algorithm: a comparative case study.

Accurate reservoir characterization is necessary to effectively monitor, manage, and increase production. A seismic inversion methodology using a genetic algorithm (GA) and particle swarm optimization (PSO) technique is proposed in this study to characterize the reservoir both qualitatively and quantitatively. It is usually difficult and expensive to map deeper reservoirs in exploratory operations when using conventional approaches for reservoir characterization hence inversion based on advanced technique (GA and PSO) is proposed in this study.

Sex-dependent association study of complement C4 gene with treatment-resistant schizophrenia and hospitalization frequency.

The complement component 4 (C4) gene, codes for two isotypes, C4A and C4B, and can exist in long or short forms (C4L and C4S). The C4AL variant has been associated with elevated schizophrenia (SCZ) risk. Here, we investigated the relationship between C4 variation and clinical outcomes in SCZ.

Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer.

The tumor microenvironment (TME) is crucial in cancer development and therapeutic response. Immunotherapy is increasingly recognized as a critical component of cancer treatment. While immunotherapies have shown efficacy in various cancers, including breast cancer, patient responses vary widely.

Technological innovation, globalization and ecological quality: A disaggregated ecological footprint approach for BRICS countries.

The ecological footprint (EF) has become one of the leading indicators for environmental assessments. The EF is an indicator that is at the center of researchers' interest in empirical analysis, as it simultaneously reflects air, water, and soil pollution. Analyzing the six sub-components of the EF is essential for assessing the environmental pressures from forestry, construction, fisheries, agriculture, and livestock, as well as for remediating these pressures.

Comparison of bone loss around submerged and non-submerged implants during osseointegration phase.

Background: In Modern dentistry, the implant is the most popular and desirable management of tooth loss. Traditionally two stage (submerged) or one-stage (non-submerged) system has been added by many investigators. In the present study we evaluated the crestal bone loss during osseointegration phase among the three groups (i.

LC-MS/MS method for simultaneous Doxorubicin and Baicalein estimation: formulation and pharmacokinetic applications.

Combinatorial delivery of Doxorubicin (DOX) and Baicalein (BAC) has a potential to improve breast cancer treatment by mitigating the cardiotoxicity induced by DOX. The nanoformulation has been optimized and subjected to pharmacokinetic studies using LC-MS/MS. Nanoformulation bearing DOX and BAC was optimized using quality by design approach and method validation was done following USFDA guidelines.

Confinement Effects of Two-Dimensional Surfaces on Water Adsorption and Dissociation over Pt(111).

It has been established that the confined space created by stacking a two dimensional (2D) surface atop a metal catalyst serves as a nano-reactor. According to recent research, when a graphene (Gr) overlayer encloses a catalyst from above, the activation barrier for the water dissociation reaction, a process with major industrial significance, decreases. In order to investigate how the effect of confinement varies among different two-dimensional (2D) materials, we study the adsorption and dissociation barriers of water molecule on (111) under graphene, hexagonal boron nitride (h-BN), and heptazine-based graphitic carbon nitride (g-CN) layers using density functional theory calculations.

The cage-free egg sector: perspectives of Indian poultry producers.

India is ranked as the 2nd largest egg producer in the world. Despite the prevalence of backyard poultry (free range), a majority of the commercial egg-laying hens in the country are still housed in battery cages. There is a global shift toward cage-free eggs, due to regulations and increased demand from conscious consumers and food corporations.

Emergence of rare and uncommon yeast-like pathogens causing neonatal sepsis at a tertiary care center, North India.

Introduction: Neonatal candidemia is a life-threatening event in babies requiring ICU admission. Prompt diagnosis and appropriate treatment reduce mortality and morbidity. Worldwide, there is an emergence of drug-resistant rare species causing neonatal sepsis that necessitates antifungal susceptibility testing in each case.

Transcarotid TAVR for Severe Bicuspid Aortic Stenosis With Virtually Atretic Coarctation of the Thoracic Aorta.

Transcatheter aortic valve replacement by alternate access sites allows for treatment of patients with unfavorable anatomy for a transfemoral approach. To our knowledge, we present the first reported case of successful transcatheter aortic valve replacement via the transcarotid approach in a 65-year-old man with a symptomatic severe bicuspid aortic valve stenosis and virtually atretic coarctation of the thoracic aorta.

Novel Thienopyrimidine-Hydrazinyl Compounds Induce DRP1-Mediated Non-Apoptotic Cell Death in Triple-Negative Breast Cancer Cells.

Apoptosis induction with taxanes or anthracyclines is the primary therapy for TNBC. Cancer cells can develop resistance to anticancer drugs, causing them to recur and metastasize. Therefore, non-apoptotic cell death inducers could be a potential treatment to circumvent apoptotic drug resistance.

Ligand-conjugated multiwalled carbon nanotubes for cancer targeted drug delivery.

Multiwalled carbon nanotubes (MWCNTs) are at the forefront of nanotechnology-based advancements in cancer therapy, particularly in the field of targeted drug delivery. The nanotubes are characterized by their concentric graphene layers, which give them outstanding structural strength. They can deliver substantial doses of therapeutic agents, potentially reducing treatment frequency and improving patient compliance.

Analysis of Co-expression of HSP 70 and BCL 2 in Oral Precancer and Cancer Patients Using Immunohistochemistry.

Introduction: Understanding of molecular model of oral carcinogenesis has carried cancer chemotherapy far forward from conventional drug therapies. Small molecule inhibitors have gained acceptance as it has fewer adverse effects and also provide targeted drug therapy. The association of HSP 70 (Heat Shock Protein 70) and BCL 2 (B-cell lymphoma 2) proteins with oral precancer and cancer is already established.

Simultaneous estimation of paclitaxel and bortezomib via LC-MS/MS: pharmaceutical and pharmacokinetic applications.

This study evaluates the potential of combining paclitaxel (PTX) and bortezomib (BTZ) for breast cancer therapy. The nanoformulation was optimized via Box-Behnken Design (BBD), with method validation adhering to US-FDA guidelines. Multiple reaction monitoring transitions for PTX, BTZ and internal standard were m/z 855.

Prevalence of anti-HLA antibodies in COVID-19 convalescent plasma donors: an Indian experience.

Background: COVID-19 convalescent plasma is one of the experimental therapies used widely in moderately sick COVID-19 patients. However, there are a few risks involved in plasma transfusion; notably, transfusion-related acute lung injury (TRALI) caused by antibodies against human leukocyte antigens (HLA). This study was designed to assess the prevalence of anti-HLA antibodies in convalescent plasma donors using the single antigen bead method.

Do bitcoin electricity consumption and carbon footprint exhibit random walk and bubbles? Analysis with policy implications.

One of the main current focuses of global economies and decision-makers is the efficiency of energy utilization in cryptocurrency mining and trading, along with the reduction of associated carbon emissions. Understanding the pattern of Bitcoin's energy consumption and its bubble frequency can greatly enhance policy analysis and decision-making for energy efficiency and carbon emission reduction. This research aims to assess the validity of the random walk hypothesis for Bitcoin's electricity consumption and carbon footprint.