The Diagnostic and Prognostic Roles Played by Homocysteine and Other Aminothiols in Patients with Chronic Kidney Disease.

We examined standard clinical and laboratory biochemical parameters, as well as the levels of aminothiols in the blood and urine (homocysteine (Hcy), cysteine (Cys), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH)) via capillary electrophoresis in patients with CKD at stages II-V. Patient outcomes were assessed after five years. To complete forecasting, correlation and ROC analysis were performed.

The Effect of Few-Layer Graphene on the Complex of Hardness, Strength, and Thermo Physical Properties of Polymer Composite Materials Produced by Digital Light Processing (DLP) 3D Printing.

The results of studying the effect of particles of few-layer graphene (FLG) synthesized by self-propagating high-temperature synthesis (SHS) on the complex of strength and thermo physical properties of polymer composite products obtained by digital light processing (DLP) 3D printing are presented. It was discovered to achieve an increase in thermophysical and strength parameters of polymers modified by FLG compared with samples made on the unmodified base resin. This result was achieved due to low defectiveness, namely the absence of Stone-Wales defects in the structure of FLG due to the homogeneous distribution of FLG over the volume of the polymer in the form of highly dispersed aggregates.

Non-contact navigated laser retinopexy for peripheral retinal tears and rhegmatogenous degenerations: first experience.

Purpose: To evaluate the first outcomes of non-contact navigated laser retinopexy for peripheral tears and rhegmatogenous degenerations of the retina.

Material And Methods: This prospective single-center interventional pilot study included 58 patients (68 eyes), among which 19 males and 39 females aged 47.5±16.

[On stomatological service in the Voronezh Oblast].

The article considers characteristics of organization of dental care for adult and children population in the territory of a large subject of the Russian Federation. In accordance with the action plan of the Health Department of the Voronezh Oblast, as well as in order to improve organization of dental services and statistical reporting and accounting in the autonomous health institution of the Voronezh Oblast, meetings concerning organization of dental services are organized. The issues are discussed concerning primary prevention of dental diseases in population of the Voronezh Oblast within the framework of the state program of the the Russian Federation "Health Care Development", organization and implementation of continuous medical education in dentistry, preparation and handing in annual report on dentistry in accordance with latest requirements of the Federal statistical monitoring in health care, new requirements of application of documents for preferential prosthetic dentistry in families of servicemen who perished during military service in peacetime.

Titanium Dichalcogenides as Nanoreactors for Magnetic High-Anisotropy Phases.

Composite single crystals consisting of nanoscaled FeSe inclusions encapsulated into the interlayer space of TiSe matrix were obtained by the decay of homogeneous FeTiSe intercalation compound. These composites have a high magnetic anisotropy due to the coherent bond between inclusions and the host lattice of TiSe. The influence of selenium pressure over the composite surface on the composition of the inclusions is studied, and the possibility of controlling their content is demonstrated.

Implementation and applications of EMOD, an individual-based multi-disease modeling platform.

Individual-based models provide modularity and structural flexibility necessary for modeling of infectious diseases at the within-host and population levels, but are challenging to implement. Levels of complexity can exceed the capacity and timescales for students and trainees in most academic institutions. Here we describe the process and advantages of a multi-disease framework approach developed with formal software support.

EFFECT OF ANTIBACTERIAL PREPARATIONS ON VIBRIO CHOLERAE EL TOR BIOFILMS.

Aim: Study the effect of antibacterial preparations on biofilms of Vibrio cholerae El Tor.

Materials And Methods: Sensitivity of V cholerae El Tor (6 strains) to various concentrations of antibacterial preparations (doxycycline,.tetracycline, levomycetin, rifampicin, gentamycin, ceftazidime) was determined (MD 4.

[The analysis of biofilms Vibrio choleraе using technique of transmissive electronic microscopy.].

The cholera continues to be one of the priority problems of world health care that determines necessity of its permanent monitoring and also further investigation of this infection in microbiological and ecological aspects. The phenomenon of biofilm formation plays a significant role among mechanisms permitting comma bacillus year by year to retain its ecological niche and to spread in various basins over a period of decades. The application of techniques of electronic microscopy played a decisive role in studying the process of biofilm formation.

[THE ROLE OF QUORUM-SENSING IN REGULATION OF FORMATION OF BIO- FILMS BY VIBRIO CHOLERAE].

Materials regarding quorum-sensing that is the main regulator of inter-cellular communications in V cholerae are presented. Information transmission between separate vibrios is executed via autoinductors. Their interaction with regulatory proteins facilitates gene activation that take part in formation of biofilms of Vcholerae which ensures their survival and spread.

[GIS: CAPABILITIES OF DATA ANALYSIS OF PHENO- AND GENOTYPING Of EL TOR 01 SEROGROUP CHOLERA VIBRIOS ISOLATED FROM AQUATIC OBJECTS OF THE ENVIRONMENT IN RUSSIA FEDERATION].

Aim: Application of the authors' GIS <> for systematization of atoxigenic strains ofserogroup 01 choleravibrios (ctxAB-tcpA-, ctxAB-tcpA+), isolated from aquatic objects of the environment by pheno- and genotype.

Materials And Methods: A sample of 304 Vibrio cholerae 01 strains was studied. Isolation of 39 genes related to pathogenicity was carried out Discrimination ability of a set of genes was determined by Simpson formula.

[VIBRIO CHOLERAE CHITINOLYTIC COMPLEX:THE COMPOSITION AND THE ROLE IN PERSISTANCE].

Reviewed the paper are the composition and functions of Vibrio cholerae chitinolytic complex which play an important role in the maintaining and creating new forms of vibrios in the environ- ment, it is better adapted to survive in environmental.

[ROLE OF BIOFILMS IN SURVIVAL AND PRESERVATION OF VIRULENCE OF CHOLERA VIBRIOS IN THE ENVIRONMENT AND HUMAN ORGANISM].

Materials regarding.biofilms of cholera vibrios are presented. Formation of biofilms is shown to be a significant pathogenicity factor and one of the main strategies, increasing survival of cholera vibrios in human organism and the environment.

[The modeling of biofilms of comma bacillus on solid surfaces (glass and plastic) and their visualization in light and luminescent microscopes].

Nowadays, necessity is shown up concerning modeling of certain ecological processes actually emerging in various biotops and hence step-by-step study of development of biofilms on solid surfaces (glass and plastic). To implement such kind of studies the light and luminescent microscopy are the most available and rather informative tools. The study used strains V.

[ACTUAL PROBLEMS OF EPIDEMIOLOGIC CONTROL, LABORATORY DIAGNOSTICS AND PROPHYLAXIS OF CHOLERA IN RUSSIAN FEDERATION].

Main problems of system of epidemiologic control for cholera active in Russian Federation, as well as laboratory diagnostics and vaccine prophylaxis of this especially dangerous infection, that had emerged in the contemporary period of the ongoing 7th pandemic of cholera, are discussed. Features of the genome of natural strains of Vibrio cholerae of El Tor biovar, that possess a poten- tial epidemic threat, as well as problems, that have emerged during isolation of these strains from samples of water of surface water bodies during their monitoring, are also examined. The main direction of enhancement of the system of epidemiologic control for cholera consist in develop- ment of a new algorithm of differentiation of administrative territories of Russian Federation by types of epidemic manifestations, as well as optimization of monitoring of environment objects.

[DETERMINATION OF TYPES OF EPIDEMIC MANIFESTATIONS OF CHOLERA IN REGIONS OF THE CRIMEA FEDERAL DISTRICT (REPUBLIC OF CRIMEA)].

The aim of the study was determination of the type of epidemic manifestations of cholera in the Republic of Crimea based on evaluation of epidemic manifestations of cholera risk of introduction and spread of the infection. It was concluded, that, based on the cholera outbreaks, that had taken place, contamination of surface water bodies (fresh and sea) and sewage by Vibrio cholerae O1 ctxA+ and Vibrio cholerae O1 ctXA- potential epidemic danger of introduction of the infection by various types of international transport, population migration, the presence of epidemiologic risk in realization of water pathway of transmission of cholera causative agent and several other social conditions, the Republic of Crimea remains in the group of territories of type I by epidemic manifestations of cholera.

[Epidemiological Surveillance of Cholera in Russia During the Period of the Seventh Pandemic].

In this work basic stages of formation of the epidemiological surveillance of cholera in Russia are described. In 1990-s for the first time zoning by epidemic manifestations of cholera was carried out at the level of subjects forming parts of Russia and other Republics of the Soviet Union with the introduction of differential tactics of epidemiological surveillance. Improvement of epidemiological surveillance of cholera was aimed at harmonization with the IHR (2005), integration of epidemiological surveillance of cholera and social-hygienic monitoring of water objects of I and II categories.

[Sensitivity to antibacterial preparations of Vibrio cholerae El Tor strains isolated from the environmental objects in Russia in 2005 - 2012].

Aim: Analysis of antibiotic resistance profiles of Vibrio cholerae O1 strains isolated from the environmental objects in the territory of Russia in 2005 - 2012.

Materials And Methods: Antibiotocograms of 52 strains of V. cholerae were determined by serial dilution method in dense nutrient medium.

Draft Genome Sequencing of Vibrio cholerae O1 El Tor Isolates Collected in the Russian Federation from Imported Cholera Cases.

We report the draft genome sequencing of five Vibrio cholerae O1 El Tor clinical isolates collected in the Russian Federation from imported cholera cases in 2006, 2010, and 2012. In the initial phylogenetic analysis, one isolate clustered with the Haiti/Nepal-4 group.

[Hydrogen peroxide as an inductor of uncultivable state of Vibrio cholerae eltor in an experiment].

The influence of hydrogen peroxide on the dynamics of transition into uncultivable state (UCS) and on the reversion of V. cholerae and their subcultures, resistant to hydrogen peroxide, was studied. The transition of the initial cultures in river and distilled water into UCS took place earlier than that in resistant to hydrogen peroxide variants.

[Dynamics of the reversible transition of Vibrio cholerae into the uncultivable state in the presence of organic and inorganic microcosmic components].

The dynamics of the transition of V. cholerae into the uncultivable state in distilled, river and tap water, containing organic and inorganic components added, was studied. As additives, potassium nitrate, potassium phosphate, magnesium sulfate, ammonium chloride, lysine, alpha-ketoglutarate, succinic acid, catalase were used.

[Hemolytic activity of Vibrio cholerae eltor and V. cholerae O139 toxigenic and nontoxigenic strains].

A total of 20 ctx- and 16 ctx+ V. cholerae eltor strains, 20 ctx- and 22 ctx+ V. cholerae O139 strains were under study.

[Laser fluorescence in assessing the hygienic status of oral cavity].

The issue related with an objective evaluation of a hygienic status of the oral cavity and a method to solve it by modern laser technologies are addressed in the paper. The efficiency of bacteriological and of laser-fluorescence express-diagnostics is comparatively analyzed. A hygienic index and its clinical value are substantiated.

[The cultivation of Vibrio cholerae with green algae in an experiment].

Relationships between Vibrio cholerae of different origin and some serogroups with green algae Scenedesmus quadricauda in mineral medium at two temperatures have been experimentally studied. Differences in the relationships of various strains with green algae under the above-mentioned experimental conditions have been established. The study has shown that a decrease in the concentration and the death of vct+ and vct- vibrios of all strains under study occur in the linear phase of the development of algae.