MEETING HIGHLIGHTS: THE THIRD MARIE SKŁODOWSKA-CURIE SYMPOSIUM ON CANCER RESEARCH AND CARE AT ROSWELL PARK COMPREHENSIVE CANCER CENTER, BUFFALO, NY, SEPTEMBER 20-22, 2023.

Marie Skłodowska-Curie Symposia on Cancer Research and Care (MSCS-CRC) promote collaborations between cancer researchers and care providers in the United States, Canada and Central and Eastern European Countries (CEEC), to accelerate the development of new cancer therapies, advance early detection and prevention, increase cancer awareness, and improve cancer care and the quality of life of patients and their families. The third edition of MSCS-CRC, held at Roswell Park Comprehensive Cancer Center, Buffalo, NY, in September 2023, brought together 137 participants from 20 academic institutions in the US, Poland, Ukraine, Lithuania, Croatia and Hungary, together with 16 biotech and pharma entities. The key areas of collaborative opportunity identified during the meeting are a) creating of a database of available collaborative projects in the areas of early-phase clinical trials, preclinical development, and identification of early biomarkers; b) promoting awareness of cancer risks and efforts at cancer prevention; c) laboratory and clinical training; and d) sharing experience in cost-effective delivery of cancer care and improving the quality of life of cancer patients and their families.

Evaluation of health-promoting self-care behaviors in hypertensive patients with concomitant chronic kidney disease in primary care.

Aim: This study was to investigate the relationships among health behaviors and quality of life (QOL) and to test a proposed model among people with hypertension and concomitant chronic kidney disease (CKD) in primary care. In addition, the mediation effect of modifiable risk factors between self-care health behaviors and QOL was examined.

Methods: This study was prospective, conducted in the centers of primary medical care in the period from January 2018 to January 2020.

CONTENT OF CATECHOLAMINES IN BLOOD SERUM OF RATS UNDER FLUORIDE INTOXICATION.

The aim of the research was to determine in the experiment the content of catecholamines in serum of rats exposed to sodium fluoride. The studies were conducted on adult Wistar rats, subjected to oral exposure by means of a probe with aqueous solutions of sodium fluoride (SF) once daily, for 60 days at doses of 1/10, 1/100 and 1/1000 DL50, which correspondingly amounts to 20 mg/kg, 2 mg/kg and 0.2 mg/kg of body weight.

NITRIC OXIDE SYNTHESIS INTENSITY ASSESSMENT BY THE CONTENT OF ITS TERMINAL STABLE METABOLITES IN THE BLOOD OF RATS UNDER FLUORIDE INTOXICATION.

The aim of the research was to evaluate the intensity of nitric oxide synthesis in the experiment by the content of its terminal stable metabolites in the blood of rats exposed to sodium fluoride. The studies were conducted on adult Wistar rats weighing 180-220 g, subjected to oral exposure by means of a probe with aqueous solutions of sodium fluoride (SF) daily for 60 days at a dose of 1/10, 1/100 and 1/1000 DL50, respectively, of 20 mg/kg, 2 mg/kg and 0.2 mg/kg body weight.

FEATURES OF LIMBIC-NEOCORTICAL AND MONOAMINERGIC CORRELATIONS IN THE DEVELOPMENT OF WITHDRAWAL SYNDROME OF INHALATIONS OF VAPORS OF ORGANIC SOLVENT «646» IN RATS.

The aim of the work was to study the limbic-neocortical and monoaminergic features of the development of withdrawal syndrome of volatile organic compounds (VOC) inhalations in rats. The study was carried out in 30 three months old male rats with dependence on inhalations of organic solvent “646” which contains up to 50 % mix of toluene and acetone. It has been shown that the withdrawal syndrome of inhalant is characterized by increased excitability and behavioral manifestations of equivalents of convulsive reactions such as oral hyperkinesis, head shaking and changes in the frequencyamplitude spectrum of the biopotentials in structures of the brain limbic-neocortical system with the initiation in the medial olfactory region and hippocampus.

Potentiated antibodies against morphine: effects on biogenic amines and lipid peroxidation in chronically morphinized rats.

The efficiency of potentiated antibodies against morphine was studied on the model of chronic morphine intoxication. Test antibodies stimulated catecholamine metabolism in the hypothalamus (i.e.

Effects of potentiated antibodies against brain-specific S100 protein on biogenic amine content and lipid peroxidation in rats under conditions of alcoholization.

Antibodies against S100 protein in ultralow doses specifically affected catecholamine metabolism in rats withdrawn from chronic ethanol exposure. The contents of tryptophan, tyrosine, and norepinephrine in brain structures returned to normal. The concentrations of dopamine, epinephrine, and norepinephrine in the peripheral blood decreased.

Effect of preparations from potentiated ethanol on the content of biogenic monoamines and metabolism of ethanol in tissues of rats during alcoholization.

The effect of homeopathically potentiated ethanol (C30 and C200) on ethanol metabolism was studied in alcoholized rats. We measured ethanol concentration in the blood, alcohol dehydrogenase activity in the liver, and contents of biogenic monoamines in the hypothalamus, septum, and whole blood. Potentiated preparations of ethanol were efficient after long-term treatment and delayed ethanol elimination from the blood.