Proteomic Analysis of Kidney Preservation Solutions Prior to Renal Transplantation.

One of the main issues in kidney transplantation is the optimal functional preservation of the organ until its transplantation into the appropriate recipient. Despite intensive efforts, the functional preservation period remains limited to hours. During this time, as a result of cellular injury, various proteins, peptides, and other molecules are released by the organ into the preservation medium.

Prophylactic Eculizumab Use in Kidney Transplantation: A Review of the Literature and Report of a Case with Atypical Hemolytic Uremic Syndrome.

Background: Atypical hemolytic uremic syndrome (aHUS) is a very rare disease, which presents with microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Progression to end-stage renal disease (ESRD) from acute kidney injury is observed in 60% of aHUS cases. The prognosis of aHUS patients who undergo kidney transplantation (Ktx) is generally poor, but these patients should be treated prophylactically with eculizumab to prevent recurrence after transplantation.

Proteinuria associated with mTOR inhibitors after kidney transplant.

Objectives: The mammalian target of rapamycin inhibitors sirolimus and everolimus are immunosuppressive drugs for kidney transplant patients, but adverse events may include proteinuria. The purpose of this study was to compare the effects of sirolimus and everolimus on creatinine clearance and proteinuria after kidney transplant.

Materials And Methods: This study was a prospective evaluation period of 50 patients (age, 16-65 y) who had kidney transplant.

Paraoxonase and arylesterase activities, lipid profile, and oxidative damage in experimental ischemic colitis model.

Objective. In the present study, since PON1 is known as an HDL-associated antioxidant enzyme that inhibits the oxidative modification of LDL and oxidative stress plays a role in the pathogenesis of mesenteric ischemia, we investigated the changes in PON1 activity and lipid profile in an experimental ischemic colitis model. Methods.

The utility of amylase and lipase as reliable predictive markers for functioning renal graft.

Background: The aim of this study was to evaluate the utility of amylase and lipase as reliable predictive markers for functioning renal grafts, either short- or long-term.

Material/methods: Serum amylase (Amyl), lipase, creatinine (Cr), creatinine clearance (Cr Cl) and 24-hr proteinuria (Prot) were studied in 190 kidney recipients. The correlation of these outcomes for each parameter was tested.

Delivery in female kidney transplant recipients with hepatitis C virus infection: is it safe for mother and newborn?

The aim of this report is to evaluate whether pregnancy is a risk factor for poor outcome of infection with hepatitis C virus or for allograft deterioration among kidney transplant recipients. The first case was in a 41-year-old pregnant kidney transplant recipient with hypercreatinemia and a history of toxic hepatitis. The second case was treated with interferon before transplant.

A possible system for optimal donor kidney exchange in Turkey.

The lack of available deceased donors and the immunological incompatibility between the patients and their voluntary donor candidates make kidney exchange among donor-patient pairs a preferable solution performed locally by many organ transplantation centers in Turkey. However, maximum benefit from kidney exchange can only be achieved when the donor patient pool is maximized using a nationwide kidney exchange program. This work discusses kidney exchange practices worldwide to develop a nationwide exchange program in Turkey and related challenges.

Ramsay Hunt syndrome with atypical progress in a renal transplant recipient: a case report.

Ramsay Hunt syndrome is a rare complication of herpes zoster disease in which reactivation of latent varicella zoster virus infection occurs in the geniculate ganglion causing otalgia, unilateral vesicular eruption in a restricted dermatomal distribution, and peripheral facial paralysis. Dermal infections caused by human pathogenic herpes viruses are common in organ transplant recipients. For a transplant surgeon, it is imperative to remember that viral prophylaxis is essential in the follow-up of the transplant patients.

Acute abdomen in pregnancy requiring surgical management: a 20-case series.

Objectives: The obstetrician often has a difficult task in diagnosing and managing the acute abdomen in pregnancy. A reluctance to operate during pregnancy adds unnecessary delay, which may increase morbidity for both mother and fetus. In this study, we present our experience in pregnant patients with acute abdomen.

Repeatability and reproducibility of landmarks--a three-dimensional computed tomography study.

The aim of this study was to investigate the repeatability and reproducibility of the placement of anthropological cephalometric landmarks on three-dimensional computed tomography (3D CT) cranial reconstructions derived from volume data sets. In addition, the influence of the observer's experience on the repeatability of landmark setting was also explored. Twenty patients without any craniofacial deformity (11 females and 9 males; age range 6.

Evaluation of efficacy and safety of mycophenolate sodium in patients with de novo and maintenance renal transplantation: results of a multicenter, prospective, observational study.

Objective: This study evaluates the effect of enteric-coated mycophenolate sodium (EC-MPS) on patient and graft survivals, the incidence of rejection episodes, and graft function among de novo and maintenance renal transplant recipients.

Patients And Methods: This open label, multicenter, prospective, post-marketing observational study of 470 renal transplantation patients at 23 centers in Turkey includes 331 de novo patients whose mean age was 29.6 ± 13.

Denervation point for neuromuscular blockade on lateral pectoral nerves: a cadaver study.

Purpose: The objective of our study was to clarify the topography of the medial and lateral pectoral nerves (LPNs) and the vascularity in the infraclavicular fossa and to propose an ideal injection point for neuromuscular blockade of the pectoralis major (PM) muscle.

Methods: The pectoral muscles and their nerves were examined bilaterally on 10 formalin-fixed cadavers. The PM muscle was dissected from its clavicular origin and sternocostal attachments.

Evaluation of intraoperative parathormone measurement for predicting successful surgery in patients undergoing subtotal/total parathyroidectomy due to secondary hyperparathyroidism.

Objectives/background: The aim of this study is to investigate the predictive value of intraoperative parathormone measurement addressing successful surgical resection in patients with secondary hyperparathyroidism.

Methods: The study included 42 consecutive patients operated on between May 2006 and July 2008. Patients were grouped according to successful surgery (Group 1, n = 36) and persistent postoperative hyperparathyroidism (Group 2, n = 6).

Does thyroid gland examination by palpation alter serum hormone levels?

Objectives/hypothesis: The goal of this study was to investigate the effects of routine thyroid gland palpation on serum thyroid hormone levels.

Study Design: Prospective study at Haydarpaşa Numune Research and Education Hospital, Istanbul, Turkey.

Methods: This study was carried out in two groups with a total of 50 consecutive adults.

Evaluation of gadolinium pre-treatment with or without splenectomy in the setting of renal ischemia reperfusion injury in rats.

Introduction: This study aims to investigate gadolinium chloride (Gd) pre-treatment with/without splenectomy (Splx) in the setting of renal ischemia/reperfusion (IR) injury in rats.

Materials And Methods: Under anesthesia, male Wistar albino rats with or without splenectomized (Splx) were right nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 3 h of reperfusion. Gadolinium chloride (10 mg kg(-1)) or saline was administered 24 hours prior to ischemia via penile vein.

Acute rejection in low-toxicity regimens: clinical impact and risk factors in the Symphony study.

The Symphony study assessed whether mycophenolate mofetil (MMF)-based regimens containing reduced doses of adjunct immunosuppressants could reduce toxicity while maintaining efficacy. Here, we examined the impact of acute rejection and associated risk factors. The incidence of biopsy-proven acute rejection in the low-dose tacrolimus group was approximately half that of the standard-dose cyclosporine and low-dose cyclosporine groups, and a third of that in the low-dose sirolimus group.

Surgical treatment of urologic complications after renal transplantation.

Aim: The incidence of urologic complications after renal transplantation has been reported to be between 2.5% and 27%. The aim of this study was to evaluate urologic complications of and their surgical treatment in our series of renal transplantations.

Medical risk analysis of renal transplant donors.

Aim: The aim of this study was to evaluate the long-term medical risks of living-related donors in our center.

Patients And Methods: 185 living-related donors participated in the study. The factors assessed were creatinine clearance rate (CrCl), serum creatinine (SCr), BUN, hematocrit levels, proteinuria, microalbuminuria and hypertension rates, and renal parenchyma thickness and kidney dimensions predonation as well as at the last follow-up.

Evaluation of pretransplant serum cytokine levels in renal transplant recipients.

Aim: Cytokines are early predictors of graft dysfunction. In this study we evaluated pretransplant cytokine levels and graft outcomes among renal transplant recipients.

Patients And Methods: Donor selection was based on results of blood group matching and negative crossmatches.

Ultrasonography-guided jugular venous catheter insertion for renal transplant recipients before renal transplantation: a prospective study.

Aim: Anatomical landmark technique for central venous catheter insertion preoperatively during renal transplantation may result in serious complications. In this prospective study, we sought to evaluate the results of ultrasonography-guided central venous catheter insertion before renal transplantation.

Patients And Methods: Since March 2004 routine ultrasonography-guided central venous catheter insertion was performed before the operation for living related renal transplantation.

Doppler ultrasonography-guided surgery for high-flow hemodialysis vascular access: preliminary results.

Aim: We sought to investigate the results of flow reduction with prospective Doppler ultrasonography (USG)-guided surgery.

Patients And Methods: Thirty patients with end-stage renal failure with high-flow arterio-venous (AV) fistulae (n = 25) or AV grafts (n = 5) were included in the study. The indications for operation were as follows: cardiac failure (n = 18) or steal syndrome (n = 12).

Quality of life analysis of renal donors.

Objective: The aim of this study was to investigate the quality of life of renal donors during long-term follow-up.

Patients And Methods: The short form health survey (SF-36) questionnaire was compared between renal donors and the general population. We evaluated the relationship to postoperative complications and preoperative information with the quality of life.

Biliary peritonitis due to "fallen" hydatid cyst after abdominal trauma.

Hepatic hydatid cysts may cause serious complications. Intraperitoneal rupture of hepatic hydatid cyst is rarely seen and the prognosis can be fatal. By experience, we know that it might be difficult to diagnose an unruptured cyst expulsed into the peritoneal cavity.

Outcome of renal allograft in Turkish patients with pretransplantation hepatitis C virus infection.

Background: The aim of the present study was to investigate the impact of hepatitis C virus (HCV) infection on the long-term survival of renal transplant recipients.

Methods: Outcomes and survivals among 325 patients who received renal allografts from July 1991 to September 2005 were compared between those known to have pretransplantation HCV infection (Group I, HCV+ group, n = 33) versus a matched cohort of those without this infection (Group II, HCV- control group, n = 33). Allograft performance, liver function, cholesterol, and glucose levels were determined both at transplantation and at a mean of postgrafting year 8.