Publications by authors named "Titir De"
Article Synopsis
- Copy number variants (CNVs) are crucial for genetic variation and evolution, but their formation and effects are not well understood, particularly concerning local genomic sequences.
- Research indicates that specific genomic features, like long terminal repeats (LTRs) and origins of DNA replication (ARS), influence the rapid formation and adaptive significance of CNVs during evolutionary processes in glutamine-limited environments.
- Experimental evolution in engineered strains shows that altering these genomic elements affects CNV formation rates and fitness, with a significant portion of CNVs linked to a mechanism called Origin Dependent Inverted Repeat Amplification (ODIRA).
Copy-number variants (CNVs) are an important class of recurrent variants that mediate adaptive evolution. While CNVs can increase the relative fitness of the organism, they can also incur a cost. We previously evolved populations of over hundreds of generations in glutamine-limited (Gln-) chemostats and observed the recurrent evolution of CNVs at the locus.
View Article and Find Full Text PDFCopy number variants (CNVs), comprising gene amplifications and deletions, are a pervasive class of heritable variation. CNVs play a key role in rapid adaptation in both natural, and experimental, evolution. However, despite the advent of new DNA sequencing technologies, detection and quantification of CNVs in heterogeneous populations has remained challenging.
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