Auto-Gait: Automatic Ataxia Risk Assessment with Computer Vision on Gait Task Videos.

Many patients with neurological disorders, such as Ataxia, do not have easy access to neurologists, -especially those living in remote localities and developing/underdeveloped countries. Ataxia is a degenerative disease of the nervous system that surfaces as difficulty with motor control, such as walking imbalance. Previous studies have attempted automatic diagnosis of Ataxia with the help of wearable biomarkers, Kinect, and other sensors.

Baseline Clinical and Blood Biomarkers in Patients With Preataxic and Early-Stage Disease Spinocerebellar Ataxia 1 and 3.

Background And Objectives: In spinocerebellar ataxia, ataxia onset can be preceded by mild clinical manifestation, cerebellar and/or brainstem alterations, or biomarker modifications. READISCA is a prospective, longitudinal observational study of patients with spinocerebellar ataxia type 1 (SCA1) and 3 (SCA3) to provide essential markers for therapeutic interventions. We looked for clinical, imaging, or biological markers that are present at an early stage of the disease.

Exploratory cross-over, trial of augmented RLS with the dopamine receptor 1/5 antagonist ecopipam D1/D5 antagonist ecopipam for augmented RLS.

Background: Restless legs syndrome (RLS) is a common condition that initially responds dramatically to dopaminergic therapy. Over time, however, dopaminergics cause augmentation, where symptoms occur earlier and intensify. Animal models suggest this may result from increased dopamine receptor type-1 affinity in the spinal cord.