Publications by authors named "Tishok Vanniyasingam"
Article Synopsis
- The study aimed to determine the effectiveness and safety of starting direct oral anticoagulants (DOACs) early versus delayed in patients with acute ischaemic stroke and atrial fibrillation.
- Conducted as a multicenter, randomized controlled trial across 100 UK hospitals, 3,648 patients were initially assigned to either early initiation (within 4 days) or delayed initiation (7-14 days) of anticoagulation.
- The primary outcome measured was the incidence of complications like recurrent stroke or bleeding within 90 days, with results being analyzed by an independent committee to ensure objectivity.
Neuroimaging shows considerable promise in generating sensitive and objective outcome measures for therapeutic trials across a range of neurodegenerative conditions. For volumetric measures the current gold standard is manual delineation, which is unfeasible for samples sizes required for large clinical trials. Using a cohort of early Huntington's disease (HD) patients ( = 46) and controls ( = 35), we compared the performance of four automated segmentation tools (FIRST, FreeSurfer, STEPS, MALP-EM) with manual delineation for generating cross-sectional caudate volume, a region known to be vulnerable in HD.
View Article and Find Full Text PDF