Cumulative neonatal oxygen exposure predicts response of adult mice infected with influenza A virus.

An acceptable level of oxygen exposure in preterm infants that maximizes efficacy and minimizes harm has yet to be determined. Quantifying oxygen exposure as an area-under-the curve (O ) has been predictive of later respiratory symptoms among former low birth weight infants. Here, we test the hypothesis that quantifying O in newborn mice can predict their risk for altered lung development and respiratory viral infections as adults.