Publications by authors named "Tirth Dave"

Article Synopsis
  • - The resurgence of Nipah virus (NiV) in Kerala poses significant public health challenges, highlighting the need for proactive strategies to prevent future outbreaks due to its zoonotic nature and changing transmission patterns.
  • - Recent NiV outbreaks have presented atypical respiratory symptoms, complicating detection efforts, and emphasize the importance of regional surveillance and understanding the virus's new genotype.
  • - A comprehensive approach involving early detection, public awareness, and strong collaboration between government and health organizations is necessary to manage the impact of NiV and ensure public safety through ongoing research.
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Article Synopsis
  • - Extra-skeletal Ewing sarcoma (EES) is a rare but aggressive tumor that affects soft tissue and is part of the primitive neuroectodermal tumors family, with only about 30 documented cases.
  • - A 20-year-old female patient experienced symptoms like shortness of breath and chest pain, leading to the discovery of a soft tissue mass that was eventually diagnosed as Ewing sarcoma through biopsy.
  • - Early detection and a multidisciplinary treatment approach, including surgical resection and chemotherapy, are crucial for improving patient outcomes, as EES often presents with non-specific symptoms and has a poor prognosis.
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Background: The introduction of ChatGPT by OpenAI has garnered significant attention. Among its capabilities, paraphrasing stands out.

Objective: This study aims to investigate the satisfactory levels of plagiarism in the paraphrased text produced by this chatbot.

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Background: Single parenthood is becoming increasingly common in today's society for various reasons such as divorce, the death of a spouse, or the choice of parenthood. Regrettably, there seems to be no significant concern among world leaders regarding depression arising from single parenting.

Aim: This article aimed to explore the prevalence of depression in single parents, the factors contributing to it, and its effects on their physical and emotional well-being.

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Article Synopsis
  • Cardiovascular disease (CVD) is a major global health issue, and this study explored the link between the TyG index and various heart-related risks in non-diabetic patients in the U.S.
  • Researchers analyzed data from over 10,000 participants from the NHANES survey (2001-2020) to assess how the TyG index relates to conditions like coronary heart disease, heart attacks, and hypertension.
  • While a higher TyG index was associated with increased cardiovascular risk factors, it was found to be a poor predictor of actual cardiovascular diseases in the studied population.
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Aims: Given the epidemic proportions of type 2 diabetes mellitus (T2DM) globally, it's crucial to comprehensively understand the factors influencing its management. The gut microbiome, known for its influence on various aspects of health, has emerged as a potential regulator of blood pressure in individuals with T2DM. This umbrella review aimed to consolidate the findings of existing meta-analyses investigating the impact of gut microbiome modulation on systolic and diastolic blood pressure in T2DM patients.

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Key Clinical Message: When treating a painless or asymptomatic mass in the submental or floor of the mouth, sublingual epidermoid cyst should be considered. Despite its irregularity, preventing malignant transformation is essential for a successful outcome.

Abstract: Dermoid and epidermoid cysts are rarely found in the head and neck region.

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Key Clinical Message: This case emphasizes the significance of COVID-19 in pediatric patients presenting with unusual hepatic manifestations, urging clinicians to broaden their diagnostic lens. The unexpected elevation of SARS-CoV-2 antibodies and the effective use of N-acetyl cysteine highlight the importance of adaptability in treatment strategies.

Abstract: This case report presents a unique manifestation of severe hepatic involvement in a 4-year-old girl with thalassemia minor and COVID-19.

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Unlabelled: This case highlights the importance of considering tuberculosis as an underlying cause of gastrointestinal amyloidosis, even in patients previously treated for the infection. Clinicians should maintain a high index of suspicion for atypical presentations of amyloidosis, especially in individuals with chronic inflammation, enabling early diagnosis and tailored management for improved patient outcomes.

Abstract: Gastrointestinal amyloidosis is a rare condition often associated with chronic inflammation.

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Parkinson disease (PD), a prevalent neurodegenerative ailment in the elderly, relies mainly on pharmacotherapy, yet deep brain stimulation (DBS) emerges as a vital remedy for refractory cases. This study performs a bibliometric analysis on DBS in PD, delving into research trends and study impact to offer comprehensive insights for researchers, clinicians, and policymakers, illuminating the current state and evolutionary trajectory of research in this domain. A systematic search on March 13, 2023, in the Scopus database utilized keywords like "Parkinson disease," "PD," "Parkinsonism," "Deep brain stimulation," and "DBS.

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Article Synopsis
  • The study aimed to assess the safety and effectiveness of zavegepant, a nasal spray for treating acute migraine attacks, by analyzing randomized clinical trials.
  • Results showed that zavegepant 10 mg significantly increased the chances of pain relief at 2 hours after dosing compared to a placebo, along with greater relief from bothersome migraine symptoms.
  • However, the zavegepant group reported more adverse events, especially taste disturbances, indicating a need for further studies to confirm its safety and efficacy across different patient populations.
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Sushruta, an ancient surgeon from 600 BCE in Kashi, India, is a pioneering figure in medical history. His innovations in surgical techniques, predating Hippocrates and Galen, have left an indelible mark in the field. This review article focuses on Sushruta's contributions to surgery, particularly his foundational work in plastic and reconstructive procedures.

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Diabetic foot ulcer is a debilitating complication of long-standing diabetes mellitus. Patients lose their earning potential, face repeated hospitalizations, and are forced to bear heavy treatment costs. This places an enormous financial burden on the patients and their families.

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Background: Testicular tumors have many different manifestations. The majority of these cases are presented as an incidental finding during hydrocelectomy. Malignant mesotheliomas are uncommon tumours that can arise from the coelomic epithelium of the pleura, peritoneum, pericardium, and tunica vaginalis.

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The chromosomal band 17q12 is characterized by a high density of genes and is bordered by segmental duplications, the structural arrangement of which increases the susceptibility of the region to deletions and duplications. Duplication of 17q12 is a rare genetic condition associated with variable characteristics from clinically asymptomatic to intellectual disabilities, seizures, and behavioral problems. The variability in phenotype is primarily due to variable expressivity and incomplete penetrance.

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Key Clinical Message: Spinal muscular atrophy (SMA) is a growing clinical concern, necessitating higher awareness and early detection. This case study focuses on the difficulties and advances in detecting and treating SMA. It emphasizes the value of early detection, interdisciplinary care, genetic testing, and novel therapeutics in terms of improving outcomes.

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Introduction And Importance: Hyper-IgE syndrome (HIES), also known as Job syndrome, is a rare primary immunodeficiency disorder characterized by elevated serum IgE levels, recurrent infections, and various clinical features. Early diagnosis, prompt management of infections, and supportive care are essential in improving outcomes for individuals with HIES. Genetic testing, including STAT3 gene sequencing, plays a crucial role in confirming the diagnosis.

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Background And Aims: The World Health Organization has recently declared the frequent outbreaks of diphtheria in Nigeria as a public health concern. Although vaccination efforts have been successful in Nigeria, unfortunately, the recent 2023 outbreak in Nigeria has been nothing short of distressing. Of course, cases of diphtheria incidence are under-reported in Nigeria.

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Anthrax outbreaks in Ghana have become a pressing public health concern, posing threats to human health, the agricultural sector, and social well-being. This letter to the editor highlights the gravity of the anthrax situation in Ghana and advocates for comprehensive interventions using a One Health approach. The epidemiology of anthrax, including its historical roots and modes of transmission, is discussed.

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