Publications by authors named "Tiquella Warner-Hatten"
J Thorac Oncol
August 2017
Article Synopsis
- IL-17A is found to be overexpressed in some lung cancer patients and may encourage tumor growth by enhancing inflammation and suppressing immune responses.
- Researchers conducted experiments using genetically modified mice to study the effects of IL-17A on lung tumors, finding faster tumor growth and poorer survival rates compared to normal controls.
- Treatment with antibodies that block IL-6 or deplete neutrophils improved outcomes in IL-17A-expressing tumors, indicating a potential therapeutic strategy for patients with this cytokine's elevation.
Cancer Discov
August 2017
Article Synopsis
- Therapies for non-small cell lung cancer (NSCLC) are challenging, but understanding oncogenic pathways has led to better therapeutic approaches that enhance the immune response against tumors.
- This study focused on two drug classes, HDAC inhibitors and bromodomain inhibitors, and found that the selective HDAC6 inhibitor, ricolinostat, improves T-cell activation and function while the bromodomain inhibitor, JQ1, reduces the suppressive effect of regulatory T cells.
- Combining these drugs showed significant antitumor effects in mouse models of lung adenocarcinomas, suggesting their potential as effective treatments for NSCLC by promoting better immune responses against cancer.
