Publications by authors named "Tiphaine Oudot-Mellkah"
Article Synopsis
- Researchers analyzed data from 14 studies involving nearly 27,000 participants to find genetic factors influencing the levels of tissue plasminogen activator (tPA), a key enzyme in blood clot breakdown.
- They identified three significant genetic loci associated with tPA levels: one linked to the STXBP5 gene on chromosome 6, another near the PLAT gene on chromosome 8, and a third related to the STX2 gene on chromosome 12.
- Functional tests showed that silencing STXBP5 reduces tPA release from cells, while silencing STX2 increases it, suggesting these genes play important roles in regulating tPA levels.