Ascorbylperoxide from parenteral nutrition induces an increase of redox potential of glutathione and loss of alveoli in newborn guinea pig lungs.

Background: Bronchopulmonary dysplasia is one of the main complications associated with extreme prematurity. Oxidative stress is suspected to be a trigger event of this lung disease, which is characterized by impaired alveolar development. Peroxides, mainly ascorbylperoxide and H2O2, are known contaminant of parenteral nutrition.

Possible predictors of cardiorespiratory events after immunization in preterm neonates.

Background: The influence of the first immunization on cardiorespiratory (CR) stability in very preterm infants is still a controversial subject.

Objectives: To describe the changes induced by immunization on heart and respiratory rate variability (HRV-RRV) and to test a potential association between preimmunization profiles and postimmunization CR events.

Methods: Continuous 72-hour CR recordings and 2.