Background: Plasmodium vivax is the dominant Plasmodium spp. causing malaria throughout tropical and sub-tropical countries. Humoral immunity is induced during P.
Systemic lupus erythematosus (SLE) is an autoimmune disease marked by the overactivity of CD4 T cells, particularly follicular helper T (TFH) cells, which are crucial for B cell maturation and antibody production.
In patients with active SLE, the study identified a significant increase in two specific cTFH subsets, cTFH1 and cTFH17, which showed memory characteristics and were positively correlated with disease activity and levels of anti-dsDNA antibodies.
The findings suggest that the activation and interactions between cTFH1, cTFH17, and certain B cell subsets may play a key role in the progression and pathology of SLE.