Exploration of the inhibitory mechanisms of trans-polydatin/resveratrol on α-glucosidase by multi-spectroscopic analysis, in silico docking and molecular dynamics simulation.

Plant-derived phenolics as natural α-glucosidase (α-GLU) inhibitors have attached great attention in the treatment of type-II diabetes mellitus currently. In this study, trans-polydatin and its aglycone resveratrol were found to show a notable inhibitory activity on α-GLU in a mixed-type manner with IC values of 18.07 and 16.

Rhodomyrtus tomentosa (Ait.) Hassk fruit phenolic-rich extract mitigates intestinal barrier dysfunction and inflammation in mice.

In this study, the mitigative effect of Rhodomyrtus tomentosa (Ait.) Hassk fruit extract rich in phenolic compounds (RTE) on high fat diet (HFD)-induced intestinal barrier dysfunction of mice and the underlying mechanism were explored. The results revealed that RTE supplementation obviously improved gut microbiota dysbiosis induced by HFD, which was evidenced by elevated alpha diversity, suppressed Firmicutes/Bacteroidetes ratio, enriched short-chain fatty acid-producing bacteria (Odoribacter, Parabacteroides, Blautia and Akkermansia), and depleted harmful bacteria (Helicobacter, norank_f_ Desulfovibrionaceae and Mucispirillum).

The effect of sonication-synergistic natural deep eutectic solvents on extraction yield, structural and physicochemical properties of pectins extracted from mango peels.

In this study, eco-friendly deep eutectic solvents (DESs) were used as extracting agents for the first time in the extraction of pectins from mango peel. Two novel green solvents including betaine-citric acid (Bet-CA) and choline chloride-malic acid (ChCl-MaA) were screened, and the extraction conditions were further optimized by full factor design experimental along with RSM. In addition, ultrasound treatment also had an influence on extraction yield, structural and physicochemical properties of extracted pectins.

Social-biological influences on sleep duration among adult residents of Northeastern China.

Background: Cold climates traditionally have conferred long sleep duration in the residents in northeast China; however, modern lifestyle reduces sleep duration. In this study, we investigated social-biological factors influencing sleep duration in the adult residents in northeast China.

Methods: This study was performed using data from the Investigation of Chronic Disease Morbidity Rate and Risk Factors of Adults in Jilin Province, China.

Preparation and identification of chicken egg yolk immunoglobulins against human enterovirus 71 for diagnosis of hand-foot-and-mouth disease.

Human enterovirus 71 (EV71) is one of the major pathogens that causes hand-foot-and mouth disease, and there is an urgent need for rapid diagnosis of EV71 virus infection for early antiviral treatment. The aim of this study was to prepare chicken egg yolk immunoglobulin Y (IgY) for the diagnosis of enterovirus type 71 infection. The antibodies were raised by intramuscular immunization of laying hens with inactivated human EV71 and isolated from the egg yolk by multiple steps of polyethylene glycol 6000 extraction.

[Investigation on rates of awareness, treatment and control of diabetes mellitus and the influence factors in rural areas of Jilin province].

Objective: Assess the rates of awareness, treatment and control of diabetes mellitus and the influence factors in rural areas of Jilin province.

Methods: Multistage stratified random cluster sampling design was used to select participants that carried out with questionnaire interview and physical examination. The analysis was based on a representative sample of 923 diabetes mellitus.

[Analysis of dyslipidemia among patients with diabetes mellitus in Jilin Province communities].

Objective: To investigate the pattern of dyslipidemia in patients with diabetes mellitus in Jilin province communities, and to provide a theoretical basis for the management of dyslipidemia among patients with diabetes.

Method: Based on the prevalence and risk factors of chronic diseases survey among adults in Jilin Province 2012 used multistage stratified random sampling design, a total of 1825 community residents aged 18 -79 years-old with diabetes mellitus in 9 districts of Jilin Province undergo the survey with questionnaire(age, gender, history of chronic disease in the past one year), blood index detection (blood glucose, total cholesterol high density lipoprotein cholesterol, low density lipoprotein cholesterol and triglycerides), and anthropometric (height and weight).

Result: Among 1825 patients with diabetes, 883 males (48.