Synergistic effects of ginsenoside Rb1 and peroxiredoxin 6 in enhancing myocardial injury treatment through anti-inflammatory, anti-oxidative, and anti-apoptotic mechanisms.

Aim: Ginsenosides have notable bioactivity in treating cardiovascular diseases, but the mechanisms of their combined use with Peroxiredoxin 6 (PRDX6) in myocardial injury remain unclear. This study explores the synergistic effects of Ginsenoside Rb1 (Gs-Rb1) and PRDX6, aiming to provide a theoretical foundation for their therapeutic potential.

Methods: We established a rat model of isoproterenol (ISO)-induced myocardial injury and observed that combination therapy was more effective than single-drug treatments, as shown by ECG monitoring and Masson staining.

Motor developmental delay in preschoolers with autism spectrum disorders in China and its association with core symptoms and maternal risk factors: a multi-center survey.

Background: Motor disturbance, as a related symptom of autism spectrum disorders (ASD), has not received the attention it deserves. We aimed to investigate the different degrees of motor developmental delay and influencing factors in Chinese preschool children with ASD, in order to enhance people's awareness of motor developmental delay in ASD children.

Methods: We recruited 1,256 ASD children aged 2-6 years from the China Multi-Center Preschool Autism Project (CMPAP).

Ntoco Promotes Ferroptosis via Hnrnpab-Mediated NF-κB/Lcn2 Axis Following Traumatic Brain Injury in Mice.

Objective: Emerging evidence highlights the involvement of long non-coding RNAs (lncRNAs) and ferroptosis in the pathogenesis of traumatic brain injury (TBI). However, the regulatory role of lncRNAs in TBI-induced ferroptosis remains poorly understood. This study aims to investigate the role of a specific lncRNA, noncoding transcript of chemokine (C-C motif) ligand 4 (Ccl4) overlapping (Ntoco), in the regulation of ferroptosis following TBI and explore its potential as a therapeutic target.

Comprehensive analysis of the effects of cooking conditions on the quality, sensory characteristics, and flavor profile of glutinous rice chicken, a Chinese traditional poultry meat product.

This study investigated the effects of cooking conditions on cooking loss, texture, and sensory attributes of glutinous rice chicken (GRC), a popular Chinese poultry dish. We compared the nutritional and sensory profiles of GRC prepared under optimal conditions (GRC-OP) with those of a commercial product (CG). Cooking time, power, and pressure significantly affected the shear force, hardness, and sensory qualities of GRC.

Advancing biohybrid robotics: Innovations in contraction models, control techniques, and applications.

Biohybrid robots have attracted many researchers' attention due to their high flexibility, adaptation ability, and high output efficiency. Under electrical, optical, and neural stimulations, the biohybrid robot can achieve various movements. However, better understanding and more precise control of the biohybrid robot are strongly needed to establish an integrated autonomous robotic system.

Phylogenomics of angiosperms based on mitochondrial genes: insights into deep node relationships.

Background: Angiosperms are the largest plant group and play an essential role in the biosphere. Phylogenetic relationships of many families and orders remain contentious, and, in an attempt to address these, we performed the most extensive sampling of mitochondrial genes to date.

Results: We reconstructed a seed plant phylogenetic framework based on 41 mitochondrial protein-coding sequences (mtCDSs), representing 335 families and 63 orders with 481 angiosperm species.

The complete chloroplast genome of (Kunze) Kitamura, 1983 (Asteraceae, Mutisieae) and its phylogenetic analysis.

Cass 1822 is a medicinally important herb in the Mutisieae tribe, Asteraceae family. This study reports the complete chloroplast (cp) genome of (Kunze) Kitamura, 1983. The quadripartite cp genome is 151,518 bp in length with 37.

Acer tegmeutosum Maxim extract alleviates acute alcohol-induced liver disease and regulates gut microbiota dysbiosis in mice.

Acer tegmentosum Maxim (AT) has a variety of pharmacological activities, however, the effects of AT on liver injury and gut microbiota in alcoholic liver disease (ALD) mice is still unclear. This study aimed to evaluate the preventive effect of AT extract on acute alcoholic liver disease. Six-week-old male C57BL/6J mice were randomly divided into 6 groups.

Unveiling emerging polycyclic aromatic compounds in the urban atmospheric particulate matter.

Despite the ubiquity and complexity of atmospheric polycyclic aromatic compounds (PACs), many of these compounds are largely unknown and lack sufficient toxicity data for comprehensive risk assessments. In this study, nontarget screening assisted by in-house and self-developed spectra databases was, therefore, employed to identify PACs in atmospheric particulate matter collected from multiple outdoor settings. Additionally, absorption, distribution, metabolism, excretion, and toxicity properties were evaluated to indicate PAC's overall abilities to cause adverse outcomes and incorporated into a novel health risk assessment model to assess their inhalation risks.

Preliminary exploration of the association of CXCR6T lymphocytes in T2D.

Type 2 diabetes (T2D) is a metabolic disease, in which inflammation is a key factor. It has been well established that T cells play important role in antigen-driven immune disorders or immune defense, but were less discussed in inflammatory metabolic diseases. However, accumulating evidences suggest that CD186 (also known as CXCR6)-positive tissue infiltrating T cells might play a key role in inflammatory metabolic diseases.

Characterization and phylogenetic analysis of the complete chloroplast genome of F. H. Chen & C. M. Hu (Asteraceae, Inuleae).

In this study, we studied the complete chloroplast (cp) genome of F. H. Chen & C.

Ufmylation: a potential modification for neurological diseases.

Neurological disorders are the leading health threats worldwide, characterized by impairments in consciousness, cognition, movement, and sensation, and can even lead to death. UFMylation is a novel post-translational modification (PTM) that serves as an important regulatory factor, promoting the complexity of protein structures and enhancing the diversity and specificity of functions. In UFMylation, ubiquitin-fold modifier 1 (UFM1) is covalently transferred to the primary amine of a lysine residue on the target protein through the synergistic action of three enzymes: the activating enzyme E1 of UFM1, the coupling enzyme E2 of UFM1, and the ligase E3.

The Intelligence Structures of School-Age Children with Attention Deficit Hyperactivity Disorder: A Multicenter Cross-Sectional Study in China.

Purpose: There is no consensus on whether cognitive measures among attention deficit hyperactivity disorder (ADHD) subtypes exhibit more similarities or differences, and most of them have been conducted on English-speaking subjects, lacking cross-cultural perspectives. The present study was aimed at investigating the intelligence structures of school-age children with ADHD who speak Chinese, using a multicenter and large sample size approach, offering some references for clinicians.

Patients And Methods: 772 children aged 6 to 12 years with ADHD took part in the cross-sectional study.

Advancing diurnal analysis of vegetation responses to drought events in the Yangtze River Basin using next-generation satellite data.

Extreme climate events, particularly droughts, pose significant threats to vegetation, severely impacting ecosystem functionality and resilience. However, the limited temporal resolution of current satellite data hinders accurate monitoring of vegetation's diurnal responses to these events. To address this challenge, we leveraged the advanced satellite ECOSTRESS, combining its high-resolution evapotranspiration (ET) data with a LightGBM model to generate the hourly continuous ECOSTRESS-based ET (HC-ET) for the middle and lower reaches of the Yangtze River Basin (YRB) from 2015 to 2022.

Combatting Helicobacter pylori: A Focus on Nanomaterials.

Developing effective non-antibiotic antimicrobial strategies is essential for combating global antibiotic resistance, including resistance stemming from Helicobacter pylori (H. pylori) treatment. Nanomaterials offer a promising and innovative approach for non-antibiotic anti-H.

Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China.

Introduction: This study aims to investigate the relationship between blood-based pathologies and established risk factors for cognitive decline in the community-based population of Chongqing, a region with significant aging.

Methods: A total of 26,554 residents aged 50 years and older were recruited. Multinomial logistic regression models were applied to assess the risk factors of cognition levels.

Effects of remote support courses on parental mental health and child development in autism: A randomized controlled trial.

Background: Sustaining the mental health of autistic children's parents can be demanding.

Aim: To determine the effect of remote support courses on the mental health of parents and the development of autistic children.

Methods: Parents of 140 autistic children were randomly assigned to two groups receiving a 2-week intervention: The control group received caregiver-mediated intervention (CMI); the experimental group received CMI with remote family psychological support courses (R-FPSC).

Lactobacillus reuteri or Lactobacillus rhamnosus GG intervention facilitates gut barrier function, decreases corticosterone and ameliorates social behavior in LPS-exposed offspring.

Probiotic therapy with Lactobacillus reuteri and Lactobacillus rhamnosus (LGG) demonstrates potential as an adjunctive treatment for autism spectrum disorder (ASD). In a rat model of ASD induced by lipopolysaccharide (LPS) injection during pregnancy, we evaluated the effects of these probiotics on offspring. Administration of L.

Microproteins encoded by short open reading frames: Vital regulators in neurological diseases.

Short open reading frames (sORFs) are frequently overlooked because of their historical classification as non-coding elements or dismissed as "transcriptional noise". However, advanced genomic and proteomic technologies have allowed for screening and validating sORFs-encoded peptides, revealing their fundamental regulatory roles in cellular processes and sparking a growing interest in microprotein biology. In neuroscience, microproteins serve as neurotransmitters in signal transmission and regulate metabolism and emotions, exerting pivotal effects on neurological conditions such as nerve injury, neurogenic tumors, inflammation, and neurodegenerative diseases.

Comprehensive Characterization of Oxidative Stress-Modulating Chemicals Using GPT-Based Text Mining.

The screening of hazardous environmental pollutants is hindered by the limited availability of toxicological databases. Large language model (LLM)-based text mining holds the potential to automatically extract complex toxicological information from the literature. Due to its relevance to diseases and the challenge of comprehensive characterization, oxidative stress serves as a suitable case for research by texting mining.

 (Primulaceae), a new species from Sichuan, China.

K.Huang & Z.X.

Phylogenomic Analysis of Dichrocephala benthamii and Comparative Analysis within Tribe Astereae (Asteraceae).

Dichrocephala benthamii C. B. Clarke has long been used as traditional Chinese medicine.