Publications by authors named "Tingyao Ma"
Introduction: Recurrent or metastatic adenoid cystic carcinoma (ACC) of the head and neck is rare and highly aggressive. Due to the ineffectiveness of immune checkpoint therapies, this study aims to investigate the tumor immune microenvironment of primary tumor tissues and lung metastatic tissues and to comprehend the challenges of immunotherapy.
Methods: We analyzed RNA sequencing data and constructed immune landscapes from 25 primary tumors and 34 lung metastases.
FOXK1 promotes hormonally responsive breast carcinogenesis by suppressing apoptosis.
Animal Model Exp Med
January 2024
Background: Globally, breast cancer constitutes the predominant malignancy in women. Abnormal regulation of epigenetic factors plays a key role in the development of tumors. Anti-apoptosis is a characteristic of tumor cells.
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- This study examines high-grade transformation (HGT) in adenoid cystic carcinoma (ACC), revealing its aggressive behavior and the serious clinical consequences for patients.
- Researchers compared 23 HGT patients to non-HGT patients, finding HGT primarily in sinonasal and lacrimal glands, with a worrying increase in lymph node metastasis, perineural invasion, and tumor growth.
- The findings indicate that patients with HGT face higher rates of recurrence and distant metastasis, suggesting they should be classified as Grade 4 due to their significantly worse survival rates compared to non-HGT cases.
Article Synopsis
- MYB-NFIB fusion and NOTCH1 mutation are common in salivary gland adenoid cystic carcinoma (SACC), but abnormal expression of these genes can also occur in patients without these mutations.
- This study used single-cell RNA sequencing to analyze two SACC patients lacking MYB-NFIB fusion and NOTCH1 mutation, identifying 25 cell types and highlighting the Notch signaling pathway in cancer cells.
- The research demonstrated that all-trans retinoic acid (ATRA) can suppress lung metastasis in SACC by correcting faulty cell differentiation linked to abnormal NOTCH1 or MYB expression, suggesting its potential role in SACC diagnosis and treatment.
Objective: Adenoid cystic carcinoma of the head and neck mainly occurs in the major salivary glands, of which the parotid gland and submandibular gland are the most common. The purpose of this study was to clarify the site-specific differences in prognosis and molecular expression characteristics of the patients and to achieve stratified risk management of the clinical prognosis.
Materials: By performing a single-centre retrospective analysis combined with analyses of the Surveillance, Epidemiology, and End Results (SEER) database, cBioPortal and GEO databases, the clinical prognostic characteristics and the differences in molecular expression patterns of ACC in the submandibular gland and parotid gland were analysed.