Publications by authors named "Tingya Wan"
The impact of dietary nutrients on tumor immunity remains an area of ongoing investigation, particularly regarding the specific role of vitamins and their mechanism. Here, we demonstrate that vitamin B3 (VB3) induces antitumor immunity against liver cancer through biased GPR109A axis in myeloid cell. Nutritional epidemiology studies suggest that higher VB3 intake reduces liver cancer risk.
View Article and Find Full Text PDFBackground: We aimed to comprehensively assess the relationship of specific dietary patterns and various nutrients with chronic kidney disease (CKD) and its progression.
Methods: The observational study data were from the NHANES 2005-2020. We calculated four dietary pattern scores (healthy eating index 2020 (HEI-2020), dietary inflammatory index (DII), alternative mediterranean diet (aMed), and dietary approaches to stop hypertension (DASH)) and the intakes of various nutrients and defined CKD, CKD-very high risk, and kidney dialysis.
Background: This study is designed to explore the correlation between multiple healthy lifestyles within the framework of "lifestyle medicine", and the mortality risk of nonalcoholic fatty liver disease (NAFLD).
Methods: The National Health and Nutrition Examination Survey (NHANES) database was employed. The analysis consisted of 5542 participants with baseline NAFLD and 5542 matched non-NAFLD participants from the database.
Background: This study aimed to estimate population-level and state-level lead-attributable mortality burdens stratified by socioeconomic status (SES) class in the USA.
Methods: Based on the National Health and Nutrition Examination Survey (NHANES), we constructed individual-level SES scores from income, employment, education and insurance data. We assessed the association between the blood lead levels (BLL) and all-cause mortality by Cox regression in the NHANES cohort (n = 31 311, 4467 deaths).
Background: Manganese (Mn) is an essential trace element with a narrow toxic margin for human health. The association between Mn exposure and adverse visceral adipose tissue (VAT) accumulation is unclear. Objective: This study aimed to estimate the associations of blood Mn levels with VAT mass or visceral obesity in the general population in the United States.
View Article and Find Full Text PDFBackground: Cadmium has been suggested to accumulate in the body over a lifetime, posing a great threat to human health. So far, few studies have studied the association between cadmium exposure and long-term health outcomes in adults.
Objectives: To investigate the risk of mortality with blood cadmium level in adults (participants of NHANES, 1999-2014).
Article Synopsis
- Di-(2-ethylhexyl) phthalate (DEHP) is a common plasticizer linked to male reproductive toxicity during prenatal development, while high fat diets (HFD) may further disrupt male reproductive function.
- A study used a mouse model to examine how prenatal DEHP exposure (0.2 mg/kg/day) combined with HFD during puberty affects testicular development, hormone levels, and sperm production in male offspring.
- Results showed that prenatal DEHP exposure decreased sperm density and testosterone, increased luteinizing hormone levels, and increased testicular cell death, with these effects worsened by subsequent HFD treatment, suggesting HFD compounds the reproductive damage from DEHP exposure.