Publications by authors named "Tingxing Yang"
Article Synopsis
- * The study identified key enzyme genes involved in the triterpenoid metabolic pathways using transcriptome sequencing and synthetic biology, particularly focusing on two 2,3-oxidosqualene cyclases and two cytochrome P450s.
- * Researchers successfully reconstructed the biosynthetic pathway for ursane and oleanane-type triterpenoids in a yeast host, detailing the enzymatic reactions necessary for producing important compounds like ursolic acid and oleanolic acid.
Efficient biosynthesis of -caryophyllene in by -caryophyllene synthase from .
Synth Syst Biotechnol
September 2024
Article Synopsis
- H. Lév. & Vaniot is a key traditional Chinese medicinal plant with valuable volatile oils, particularly sesquiterpenoids, which are under-researched in terms of their biosynthesis.
- The study successfully identified four -caryophyllene synthases and developed a high-yield engineered cell factory that achieved a remarkable production level of -caryophyllene at 15.6 g/L through fed-batch fermentation.
- This achievement marks the highest yield of -caryophyllene produced in yeast to date, paving the way for its potential industrial-scale production.