Clinical characteristics and MRI features of autoimmune glial fibrillary acidic protein astrocytopathy: a case series of 34 patients.

Objectives: To analyze the clinical and imaging characteristics of autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A).

Methods: Forty-three patients diagnosed with GFAP-A between March 2017 and July 2023 were retrospectively recruited. The clinical characteristics and magnetic resonance imaging (MRI) features were collected.

Research progress in the application of colloidal motors for precision medicine.

Colloidal motors have unique capabilities of self-propulsion, cargo loading and active target delivery, and have great potential for precision disease therapy. Currently, colloidal motors with different functions have been designed for diverse disease treatments. However, the application of colloidal motors in precision disease treatment is still in the exploratory stage and faces many practical challenges.

AIE-active polysiloxane-based fluorescent probe for identifying cancer cells by locating lipid drops.

Comparing with normal cells, Lipid droplets (LDs) of cancer cells show lower polarity and less quantity, which can be utilized as a marker for cancer diagnosis. However, the investigation of LDs in living cancer cells is restricted by the lack of effective molecular tools. Herein, we first reported a novel polysiloxane-based polymer fluorescent polar probe TR-1 with AIE properties, which realized the possibilities for locating LDs.

Triphenylamine Schiff base as a lipid droplet-targeted fluorescent probe using Si-O-Si as a bridge for the detection of Cr applied in bio-imaging.

Lipid droplets are known to play an important role in many cellular activities, as revealed by recent studies. Additionally, hexavalent chromium is considered extremely toxic because it readily passes through cellular membranes and easily accumulates in living cells. In this study, a novel lipid droplet-targeted fluorescent probe (Si-LDS) for recognition of Cr6+ in living cells was designed and synthesized using triphenylamine derivatives and organosiloxane.

Novel fluorene-based fluorescent probe with excellent stability for selective detection of SCN and its applications in paper-based sensing and bioimaging.

SCN- is one of the most important anions in metabolic processes. However, the investigation of SCN- in living systems is restricted by the lack of stable functional molecular tools. Herein, the first fluorene-based polymer fluorescent probe V1 was synthesized through rational design.

Novel fluorescent probe with a bridged Si-O-Si bond for the reversible detection of hypochlorous acid and biothiol amino acids in live cells and zebrafish.

Herein, we report the design of a novel fluorescent probe consisting of a naphthalimide fluorophore and a silicone small molecule for the reversible detection of hypochlorous acid and biothiol amino acids. The response mechanism of BSi-1 is based on the concept of the S-based oxidation/reduction. The probe was found to be suitable for imaging HOCl in HeLa, RAW 264.

Novel polysiloxane-based rhodamine B fluorescent probe for selectively detection of Al and its application in living-cell and zebrafish imaging.

Polysiloxanes have excellent stability and biological relevance and are suitable for biological research. However, there were few polysiloxane-based fluorescent probes for bioimaging. This report successfully designed a new polysiloxane-based polymer fluorescent probe (RB-1) for the first time as a "turn-on" fluorescent probe response to Al ion with highly sensitive and selectivity.

Binding Reaction Sites to Polysiloxanes: Unique Fluorescent Probe for Reversible Detection of ClO/GSH Pair and the in Situ Imaging in Live Cells and Zebrafish.

PDMS is biocompatible, economically viable, transparent, and facile to handle and thus is suitable for fluorescent microscopy and biological research. However, there has been no report about polysiloxane-based fluorescent probes applied in bioimaging. In this report, a two-photon polysiloxane-based reversible luminescent probe (P1) was fabricated for the first time.

Silica Nanoparticles with Up-conversion Fluorescence Based on Triplet-Triplet Annihilation Mechanism for Specific Recognition of Apoptosis Cells.

Discrimination of live and apoptotic cells is a crucial task in the research of pharmacology, biology, pathology, and medicine science. Recently, up-conversion (UC) luminescent materials have appealed much attention due to their unique ability to convert low energy excitation photons to high energy ones. However, UC fluorescence has not been employed in the field of discrimination of live and apoptotic cells.

Thermally Responsive Materials for Bioimaging.

The last decade has witnessed multiple thermally responsive materials emerge as a significant class of stimuli-responsive materials. These materials are elaborately designed and exert interesting properties. Herein, an overview of thermally responsive materials with respect to design strategies, fabrication procedures, and their applications is presented.